Mei Qiaojuan, Mou Hongbei, Liu Xuemei, Xiang Wenpei
Institute of Reproductive Health and Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Reproductive Medicine Centre, Yantai Yuhuangding Hospital of Qingdao University, Shandong, China.
Front Cell Dev Biol. 2021 May 10;9:650003. doi: 10.3389/fcell.2021.650003. eCollection 2021.
With the development of regenerative medicine, stem cells are being considered more frequently for the treatment of reproductive aging. Human umbilical cord mesenchymal stem cells have been reported to improve the reserve function of aging ovaries through their homing and paracrine effects. In this process, paracrine factors secreted by stem cells play an important role in ovarian recovery. Although the transplantation of human umbilical cord mesenchymal stem cells to improve ovarian function has been studied with great success in animal models of reproductive aging, their application in clinical research and therapy is still relatively rare. Therefore, this paper reviews the role of human umbilical cord mesenchymal stem cells in the treatment of reproductive aging and their related mechanisms, and it does so in order to provide a theoretical basis for further research and clinical treatment.
随着再生医学的发展，干细胞越来越频繁地被考虑用于治疗生殖衰老。据报道，人脐带间充质干细胞通过其归巢和旁分泌作用改善衰老卵巢的储备功能。在此过程中，干细胞分泌的旁分泌因子在卵巢恢复中起重要作用。尽管在生殖衰老动物模型中，人脐带间充质干细胞移植改善卵巢功能的研究取得了巨大成功，但其在临床研究和治疗中的应用仍然相对较少。因此，本文综述了人脐带间充质干细胞在治疗生殖衰老中的作用及其相关机制，以便为进一步的研究和临床治疗提供理论依据。
