Institute of Reproductive Health, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sci Adv. 2020 May 22;6(21):eaba6357. doi: 10.1126/sciadv.aba6357. eCollection 2020 May.
Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinked hyaluronic acid gel (HA-GEL) on endometrial damage and adhesion. Here, we recorded the menstrual cycle data in detail with uterine cavities observed and endometrial tissues detected after intervention, and the thicker endometria, decreased amount of fibrotic formation, increased number of endometrium glands, etc., suggested that both HA-GEL and huMSC/HA-GEL complexes could partially repair IUA caused by mechanical injury, but huMSC/HA-GEL complex transplantation had notable dual repair effects: a reliable antiadhesion property and the promotion of endometrial regeneration.
宫腔粘连（IUA）发生率的增加严重影响了人类的生活质量。本研究旨在建立非人灵长类动物的 IUA 模型，并探讨负载人脐带间充质干细胞（huMSCs）的自交联透明质酸凝胶（HA-GEL）对子宫内膜损伤和粘连的双重修复作用。在这里，我们详细记录了月经周期数据，并在干预后观察了子宫腔和子宫内膜组织，结果显示较厚的子宫内膜、减少的纤维化形成量、增加的子宫内膜腺体数量等，表明 HA-GEL 和 huMSC/HA-GEL 复合物都可以部分修复机械损伤引起的 IUA，但 huMSC/HA-GEL 复合物移植具有显著的双重修复作用：可靠的抗粘连特性和促进子宫内膜再生。
