皮质下核团在阿尔茨海默病型老年痴呆中的不同受累情况。
The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type.
作者信息
Wilcock G K, Esiri M M, Bowen D M, Hughes A O
机构信息
Department of Care of the Elderly, Frenchay Hospital, Bristol, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):842-9. doi: 10.1136/jnnp.51.6.842.
Abstract
Cell counts have been performed on cholinergic subcortical nuclei, dorsal raphe nucleus, and locus caeruleus from up to 18 cases of Alzheimer's disease and 10 age-matched control subjects. In general, the extent of cell loss in these structures was similar. In the basal nucleus the anteromedial subdivision was the least, and the posterior subdivision the most affected. A subgroup of demented subjects with Alzheimer's disease had a relatively preserved basal nucleus, and frontal lobe (CAT) choline acetyltransferase activities similar to those in control subjects, but significantly more neuronal loss in the locus caeruleus.
摘要
已对多达18例阿尔茨海默病患者和10名年龄匹配的对照受试者的胆碱能皮质下核、中缝背核和蓝斑进行了细胞计数。总体而言，这些结构中的细胞丢失程度相似。在基底核中，前内侧亚区受影响最小，而后亚区受影响最大。阿尔茨海默病痴呆受试者的一个亚组基底核相对保留，额叶（CAT）胆碱乙酰转移酶活性与对照受试者相似，但蓝斑中的神经元丢失明显更多。
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