一株人源多重耐药大肠杆菌中同时携带 IncHI2 质粒、 和 基因的双重拷贝。
First IncHI2 Plasmid Carrying , , and Double Copies of in a Multidrug-Resistant Escherichia coli Human Isolate.
机构信息
Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy.
Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.
出版信息
mSphere. 2021 Jun 30;6(3):e0030221. doi: 10.1128/mSphere.00302-21. Epub 2021 May 28.
We report a novel IncHI2 plasmid coharboring , two copies of , and resistance genes in a human Escherichia coli isolate of the new serogroup O188. The gene was included in a class 1 integron, in a cassette bracketed by IS and ΔIS1R, and in two copies within a new composite Tn-like transposon. The emergence of carbapenem and colistin resistance genes in a single plasmid is of great concern for upcoming clinical therapies.
我们报告了一种新型的 IncHI2 质粒，它共携带两个 、和 耐药基因，存在于一株新型血清群 O188 的人源大肠埃希菌中。 基因位于一个整合子的第 1 类，由 IS 和 ΔIS1R 框定的盒内，另外两个位于一个新的复合 Tn 样转座子内。单个质粒中碳青霉烯类和多粘菌素类耐药基因的出现，对未来的临床治疗极具威胁。
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