Chailakhyan R K, Mishina E S, Grosheva A G, Vorob'eva N N, Khachiyants V I, Inshakov Yu M, Gerasimov Yu V, Kuralesova A I, Moskvina I L
N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Kursk State Medical University, Kursk, Russia.
Bull Exp Biol Med. 2021 May;171(1):134-140. doi: 10.1007/s10517-021-05185-5. Epub 2021 May 29.
We studied the formation of the reparative regenerate of the skin wound in rats under the effect of drug products based on keratan and secretome of bone marrow mesenchymal stem cells (MSC), as well as bone marrow cells (native and exposed to laser radiation with a wavelength of 1.56 μm). Due to the biological affinity for the dermal tissue, keratan preparations being applied to the skin stimulate regeneration of the wound defect. This substance in the form of a gel is characterized by high diffusion capacity, penetrates into the deeper layers of the dermis, and promotes the growth of the granulation tissue. Application of an ointment prepared on the basis of MSC secretome promotes quick transition of the healing process from the inflammatory to the regenerative stage. Thus, bone marrow cells were successfully used for skin wound healing. The results of the use of bone marrow cells for the healing of skin wounds were successful; bone marrow exposed to laser radiation demonstrated high efficiency in promoting reparative processes.
我们研究了基于角蛋白和骨髓间充质干细胞（MSC）分泌组以及骨髓细胞（天然的和暴露于波长为1.56μm激光辐射的骨髓细胞）的药物产品作用下大鼠皮肤伤口修复性再生的形成。由于对角质组织具有生物亲和力，将角蛋白制剂应用于皮肤可刺激伤口缺损的再生。这种凝胶形式的物质具有高扩散能力，可渗透到真皮深层，并促进肉芽组织生长。应用基于MSC分泌组制备的软膏可促进愈合过程从炎症阶段快速过渡到再生阶段。因此，骨髓细胞已成功用于皮肤伤口愈合。使用骨髓细胞治疗皮肤伤口取得了成功；暴露于激光辐射的骨髓在促进修复过程方面显示出高效率。
