School of Human Nutrition, McGill University, Ste. Anne de Bellevue, QC, Canada.
Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
Prog Mol Subcell Biol. 2021;59:1-11. doi: 10.1007/978-3-030-67696-4_1.
Calreticulin is well known as an ER-resident protein that serves as the major endoplasmic reticulum (ER) Ca binding protein. This protein has been the major topic of discussion in an international workshop that has been meeting for a quarter of a century. In sharing information about this protein, the field also witnessed remarkable insights into the importance of the ER as an organelle and the role of ER Ca in coordinating ER and cellular functions. Recent technological advances have helped to uncover the contributions of calreticulin in maintaining Ca homeostasis in the ER and to unravel its involvement in a multitude of cellular processes as highlighted in this collection of articles. The continuing revelations of unexpected involvement of calreticulin and Ca in many critical aspects of cellular function promises to further improve insights into the significance of this protein in the promotion of physiology as well as prevention of pathology.
钙网蛋白是众所周知的内质网驻留蛋白，作为主要的内质网（ER）Ca 结合蛋白。这个蛋白质一直是一个国际研讨会的主要讨论话题，这个研讨会已经开了四分之一个世纪了。在分享有关这个蛋白质的信息的同时，该领域还见证了内质网作为细胞器的重要性以及内质网 Ca 在协调内质网和细胞功能方面的作用的显著认识。最近的技术进步有助于揭示钙网蛋白在维持内质网 Ca 动态平衡中的贡献，并阐明其在众多细胞过程中的作用，正如本论文集中所强调的那样。钙网蛋白和 Ca 在内质网的 Ca 稳态维持和许多细胞功能的关键方面的意外作用的不断揭示，有望进一步提高对这种蛋白在促进生理学和预防病理学方面的重要性的认识。
