Department of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Dairy Research Institute, Bright Dairy & Food Co., Ltd, Shanghai, China.
Pharm Biol. 2021 Dec;59(1):647-652. doi: 10.1080/13880209.2021.1929344.
Upper respiratory tract infection (URTI) is the most common illness in humans. Fermented milk containing probiotics can mitigate URTI symptoms.
This study tests the effect of fermented milk (Qingrun), a yogurt supplemented with subsp. Bl-04, on adults with URTIs who live in a haze-covered area in a randomized clinical trial.
A total of 136 subjects were enrolled in the study at the baseline and randomized to consume either control yogurt or Qingrun yogurt (250 g) once daily for 12 weeks. The duration and severity of URTI were evaluated by the Wisconsin Upper Respiratory Symptom Survey-24. Blood and faecal samples were collected at the baseline and post-intervention, to determine the changes of immune biomarkers.
Qingrun yogurt significantly reduced the incidence of the common cold (OR, 0.38; 95% CI, 0.17-0.81; = 0.013) and influenza-like illness (OR, 0.32; 95% CI, 0.11-0.97; = 0.045). Compared to the control yogurt, Qingrun yogurt significantly reduced the duration (1.23 ± 2.73 vs. 4.78 ± 5.09 d) and severity score (3.58 ± 7.12 vs. 11.37 ± 11.73) of URTI. In addition, the post-intervention levels of interferon-γ (139.49 ± 59.49 vs. 113.45 ± 65.12 pg/mL) and secretory immunoglobulin A (529.19 ± 91.70 vs. 388.88 ± 53.83 mg/dL) significantly increased in the Qingrun group, compared with those in the control group.
Qingrun yogurt showed a protective effect against URTI in adults, suggesting that the use of yogurt with probiotics could be a promising dietary supplement for mitigating URTI.
上呼吸道感染（URTI）是人类最常见的疾病。含有益生菌的发酵乳可以减轻 URTI 症状。
本研究通过一项随机临床试验，测试在雾霾地区生活的 URTI 成人饮用添加了 subsp. Bl-04 的酸奶（Qingrun）对 URTI 的影响。
在研究的基线阶段，共有 136 名受试者被纳入研究，并随机分为对照组（食用普通酸奶）和 Qingrun 组（食用 Qingrun 酸奶，每天 250g），两组均连续 12 周。采用威斯康星州上呼吸道症状调查-24 量表评估 URTI 的持续时间和严重程度。在基线和干预后采集血液和粪便样本，以确定免疫生物标志物的变化。
与对照组相比，Qingrun 组普通感冒（OR，0.38；95%CI，0.17-0.81； = 0.013）和流感样疾病（OR，0.32；95%CI，0.11-0.97； = 0.045）的发病率显著降低。与对照组相比，Qingrun 组 URTI 的持续时间（1.23±2.73 比 4.78±5.09d）和严重程度评分（3.58±7.12 比 11.37±11.73）均显著降低。此外，与对照组相比，干预后 Qingrun 组干扰素-γ（139.49±59.49 比 113.45±65.12pg/mL）和分泌型免疫球蛋白 A（529.19±91.70 比 388.88±53.83mg/dL）的水平显著升高。
Qingrun 酸奶对成人 URTI 具有保护作用，提示使用含益生菌的酸奶可能是缓解 URTI 的一种有前途的膳食补充剂。
