Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
School of Life Sciences, Henan University, Kaifeng 475004, China.
Biomolecules. 2021 May 1;11(5):682. doi: 10.3390/biom11050682.
Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (HS) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of HS for respiratory diseases has been widely investigated. HS plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of HS has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of HS in respiratory diseases. Besides, we also summarized HS production in the lung and its metabolism processes in respiratory diseases.
呼吸系统疾病是全球范围内导致死亡和残疾的主要原因，涉及多种健康问题。由于发病率和死亡率的不断上升，呼吸系统疾病和感染的治疗一直被认为是具有挑战性的。硫化氢（HS）是参与广泛的细胞功能以及各种疾病（包括呼吸系统疾病）的生理和病理过程的公认气体递质之一。最近，HS 治疗呼吸系统疾病的潜力已得到广泛研究。HS 在阻塞性呼吸疾病、肺纤维化、肺气肿、胰腺炎症/呼吸性肺损伤、肺部炎症、支气管哮喘和支气管扩张症中发挥着重要的治疗作用。尽管 HS 在各种呼吸系统疾病中的治疗作用已经得到广泛研究，但具体的文献综述将对未来的治疗产生巨大影响。本文综述了 HS 在呼吸系统疾病中的有效作用。此外，我们还总结了 HS 在肺部的产生及其在呼吸系统疾病中的代谢过程。
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