Vajda Jernej, Milojević Marko, Maver Uroš, Vihar Boštjan
Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
Department of Pharmacology, Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia.
Biomedicines. 2021 May 21;9(6):589. doi: 10.3390/biomedicines9060589.
Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale-the microvasculature-that are crucial for oxygen and nutrient delivery. In this review, we present the state of the art in the field of microvascular tissue engineering and demonstrate the challenges for future research in various sections of the field. Finally, we illustrate the potential strategies for addressing some of those challenges.
近几十年来，组织工程和再生医学取得了长足的进步，但缺乏功能性脉管系统仍是阻碍更厚的、具有生理相关性的组织构建物发展的主要障碍。这一障碍很大程度上在于微血管层面（即微脉管系统）血管的发育，而微脉管系统对于氧气和营养物质的输送至关重要。在本综述中，我们介绍了微血管组织工程领域的最新进展，并阐述了该领域各个部分未来研究面临的挑战。最后，我们说明了应对其中一些挑战的潜在策略。
