Jabeen Mehwish, Dutot Mélody, Fagon Roxane, Verrier Bernard, Monge Claire
Laboratory of Tissue Biology and Therapeutic Engineering, UMR5305 Centre National de la Recherche Scientifique/Université Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
Recherche & Développement, Yslab, 29000 Quimper, France.
Pharmaceutics. 2021 May 16;13(5):733. doi: 10.3390/pharmaceutics13050733.
Respiratory viral infections have been a leading cause of morbidity and mortality worldwide. Despite massive advancements in the virology field, no specific treatment exists for most respiratory viral infections. Approved therapies against respiratory viruses rely almost exclusively on synthetic drugs that have potential side effects, restricting their use. This review aims to present natural marine sulfated polysaccharides possessing promising antiviral activity against respiratory viruses that could be a safe alternative to synthetic broad-spectrum antiviral drugs. The antiviral properties of marine sulfated polysaccharides are presented according to their mechanism of action on different types and strains of respiratory viruses, and the potential limits of their use are discussed.
呼吸道病毒感染一直是全球发病和死亡的主要原因。尽管病毒学领域取得了巨大进展，但大多数呼吸道病毒感染仍没有特效治疗方法。获批的抗呼吸道病毒疗法几乎完全依赖具有潜在副作用的合成药物，这限制了它们的使用。本综述旨在介绍具有有望抗呼吸道病毒活性的天然海洋硫酸化多糖，它们可能是合成广谱抗病毒药物的安全替代品。根据海洋硫酸化多糖对不同类型和毒株呼吸道病毒的作用机制介绍其抗病毒特性，并讨论其使用的潜在局限性。
