纳米粒子在乳腺癌治疗中的应用。
The use of nanoparticulates to treat breast cancer.
机构信息
Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
Department of Materials Science & Engineering, Pennsylvania State University, University Park, PA 16802, USA.
出版信息
Nanomedicine (Lond). 2017 Oct;12(19):2367-2388. doi: 10.2217/nnm-2017-0202. Epub 2017 Sep 4.
Abstract
Breast cancer is a major ongoing public health issue among women in both developing and developed countries. Significant progress has been made to improve the breast cancer treatment in the past decades. However, the current clinical approaches are invasive, of low specificity and can generate severe side effects. As a rapidly developing field, nanotechnology brings promising opportunities to human cancer diagnosis and treatment. The use of nanoparticulate-based platforms overcomes biological barriers and allows prolonged blood circulation time, simultaneous tumor targeting and enhanced accumulation of drugs in tumors. Currently available and clinically applicable innovative nanoparticulate-based systems for breast cancer nanotherapies are discussed in this review.
摘要
乳腺癌是发展中国家和发达国家女性面临的一个重大公共卫生问题。在过去几十年中，在改善乳腺癌治疗方面取得了重大进展。然而，目前的临床方法具有侵入性、特异性低，并可能产生严重的副作用。作为一个快速发展的领域，纳米技术为人类癌症的诊断和治疗带来了有希望的机会。基于纳米颗粒的平台的使用克服了生物屏障，允许延长血液循环时间、同时靶向肿瘤并增强药物在肿瘤中的积累。本文综述了目前可用于乳腺癌纳米治疗的创新型基于纳米颗粒的系统。
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