Institute of Microelectronics, A*STAR (Agency for Science, Technology and Research), Singapore 138634, Singapore.
KK Women's & Children's Hospital, Singapore 229899, Singapore.
Sensors (Basel). 2021 May 14;21(10):3429. doi: 10.3390/s21103429.
Extravasation is a complication of intravenous (IV) cannulation in which vesicant drugs leak from a vein into the surrounding subcutaneous tissue. The severity of extravasation depends on the type, concentration, and volume of drugs that accumulate in the subcutaneous tissue. Rapid detection of extravasation can facilitate prompt medical intervention, minimizing tissue damage, and preventing adverse events. In this study, we present two portable sensor patches, namely gold- and carbon-based sensing patches, for early detection of extravasation. The gold-based sensor patch detected extravasated fluid of volume as low as 2 mL in in vivo animal models and human clinical trials; the patch exhibited a resistance change of 41%. The carbon-based sensor patch exhibited a resistance change of 51% for 2 mL of extravasated fluid, and fabrication throughput and cost-effectiveness are superior for this patch compared with the gold-based sensing patch.
外渗是静脉（IV）插管的一种并发症，其中刺激性药物从静脉漏到周围的皮下组织中。外渗的严重程度取决于积聚在皮下组织中的药物的类型、浓度和体积。快速检测外渗可以促进及时的医疗干预，最大限度地减少组织损伤，并防止不良事件的发生。在这项研究中，我们提出了两种便携式传感器贴片，即金基和碳基传感贴片，用于早期检测外渗。金基传感器贴片在体内动物模型和人体临床试验中检测到体积低至 2 毫升的外渗液；该贴片表现出 41%的电阻变化。碳基传感器贴片对 2 毫升外渗液表现出 51%的电阻变化，与金基传感贴片相比，这种贴片具有更高的制造吞吐量和成本效益。
