School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Nat Biomed Eng. 2024 Aug;8(8):963-976. doi: 10.1038/s41551-023-01116-z. Epub 2023 Oct 30.
The high stiffness of intravenous needles can cause tissue injury and increase the risk of transmission of blood-borne pathogens through accidental needlesticks. Here we describe the development and performance of an intravenous needle whose stiffness and shape depend on body temperature. The needle is sufficiently stiff for insertion into soft tissue yet becomes irreversibly flexible after insertion, adapting to the shape of the blood vessel and reducing the risk of needlestick injury on removal, as we show in vein phantoms and ex vivo porcine tissue. In mice, the needles had similar fluid-delivery performance and caused substantially less inflammation than commercial devices for intravenous access of similar size. We also show that an intravenous needle integrated with a thin-film temperature sensor can monitor core body temperature in mice and detect fluid leakage in porcine tissue ex vivo. Temperature-responsive intravenous needles may improve patient care.
静脉注射针的高刚性会导致组织损伤，并增加通过意外针刺传播血源性病原体的风险。在这里，我们描述了一种静脉注射针的开发和性能，其刚性和形状取决于体温。该针足够硬，可以插入软组织，但插入后会不可逆地变得灵活，适应血管的形状，从而降低拔出时针刺损伤的风险，我们在静脉模型和离体猪组织中证明了这一点。在小鼠中，这些针具有相似的输液性能，并且比类似尺寸的用于静脉穿刺的商业设备引起的炎症少得多。我们还表明，与薄膜温度传感器集成的静脉内针可以监测小鼠的核心体温，并检测离体猪组织中的液体泄漏。温度响应型静脉内针可能会改善患者护理。
