基于污水的流行病学作为 SARS-CoV-2 及其变异株在人群中传播的早期预警系统。
Wastewater-Based Epidemiology as an Early Warning System for the Spreading of SARS-CoV-2 and Its Mutations in the Population.
机构信息
Department of Environmental Engineering, Institute of Chemical and Environmental Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
Department of Inorganic Technology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
出版信息
Int J Environ Res Public Health. 2021 May 25;18(11):5629. doi: 10.3390/ijerph18115629.
New methodologies based on the principle of "sewage epidemiology" have been successfully applied before in the detection of illegal drugs. The study describes the idea of early detection of a virus, e.g., SARS-CoV-2, in wastewater in order to focus on the area of virus occurrence and supplement the results obtained from clinical examination. By monitoring temporal variation in viral loads in wastewater in combination with other analysis, a virus outbreak can be detected and its spread can be suppressed early. The use of biosensors for virus detection also seems to be an interesting application. Biosensors are highly sensitive, selective, and portable and offer a way for fast analysis. This manuscript provides an overview of the current situation in the area of wastewater analysis, including genetic sequencing regarding viral detection and the technological solution of an early warning system for wastewater monitoring based on biosensors.
基于“污水流行病学”原理的新方法以前曾成功应用于非法药物的检测。本研究描述了在污水中早期检测病毒（例如 SARS-CoV-2）的想法，以便关注病毒发生的区域，并补充临床检查的结果。通过监测污水中病毒载量的时间变化并结合其他分析，可以检测到病毒爆发并尽早抑制其传播。生物传感器在病毒检测中的应用似乎也是一个有趣的应用。生物传感器具有高灵敏度、选择性和便携性，为快速分析提供了一种方法。本文概述了污水分析领域的现状，包括病毒检测的遗传测序以及基于生物传感器的污水监测预警系统的技术解决方案。
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