高血压患者视网膜微血管、心血管风险与无症状脑梗死之间的关系
Relationship between Retinal Microvasculature, Cardiovascular Risk and Silent Brain Infarction in Hypertensive Patients.
作者信息
Forés Rosa, Manresa Josep M, López-Lifante Victor M, Heras Antonio, Delgado Pilar, Vázquez Xose, Ruiz Susana, Alzamora Maria Teresa, Toran Pere
机构信息
Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain.
Riu Nord-Riu Sud Primary Healthcare Centre, Santa Coloma de Gramenet, Gerència d'Àmbit d'Atenció Primària Metropolitana Nord, Institut Català de la Salut, 08921 Barcelona, Spain.
出版信息
Diagnostics (Basel). 2021 May 24;11(6):937. doi: 10.3390/diagnostics11060937.
OBJECTIVE
The aims of this study are to analyze the role of artery-vein ratio AVR assessment using VesselMap 2 software (Imedos Systems) and cardiovascular risk evaluation by means of REGICOR in the prediction of silent brain infarction (SBI) in middle-age hypertensive patients from the ISSYS study.
MATERIAL AND METHODS
A cross-sectional study with 695 patients with hypertension aged 50 to 70 years who participated in the project (ISSYS), was conducted in two Primary Care Centres of Barcelona. Participants agreed to a retinography and an MRI to detect silent brain infarction (SBI). The IMEDOS software was used for the semiautomatic caliber measurement of retinal arteries and veins, and the AVR was considered abnormal when <0.66. The REGICOR score was calculated for all patients.
RESULTS
Multivariate logistic regression analysis was used to evaluate the impact of AVR and REGICOR scores on SBI. The OR (odds ratio) for a high REGICOR score and an abnormal AVR were 3.16 and 4.45, respectively. When analysing the interaction of both factors, the OR of an abnormal AVR and moderate REGICOR score was 3.27, whereas with a high REGICOR score it reached 13.07.
CONCLUSIONS
The measurement of AVR in patients with hypertension and with a high REGICOR score can contribute to the detection of silent brain infarction.
目的
本研究旨在分析使用VesselMap 2软件（Imedos Systems）评估动静脉比（AVR）以及通过REGICOR进行心血管风险评估在预测来自ISSYS研究的中年高血压患者无症状脑梗死（SBI）中的作用。
材料与方法
在巴塞罗那的两个初级保健中心对695名年龄在50至70岁之间参与该项目（ISSYS）的高血压患者进行了一项横断面研究。参与者同意进行视网膜造影和MRI以检测无症状脑梗死（SBI）。使用IMEDOS软件对视网膜动脉和静脉进行半自动管径测量，当AVR<0.66时认为其异常。为所有患者计算REGICOR评分。
结果
采用多变量逻辑回归分析来评估AVR和REGICOR评分对SBI的影响。高REGICOR评分和异常AVR的比值比（OR）分别为3.16和4.45。在分析这两个因素的相互作用时，异常AVR和中度REGICOR评分的OR为3.27，而高REGICOR评分时则达到13.07。
结论
对高血压且REGICOR评分高的患者进行AVR测量有助于检测无症状脑梗死。
Zotero 插件