头孢唑林和利福平治疗期间的凝血障碍：罕见但危险。
Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous.
作者信息
Kouki Ines, Montagner Clémence, Mauhin Wladimir, London Jonathan, Lazard Thierry, Grimbert Sylvie, Zeller Valérie, Lidove Olivier
机构信息
Service de Médecine Interne, Groupe Hospitalier Diaconesses - Croix Saint-Simon, 125 rue d'Avron, 75020, Paris, France.
Service de Réanimation, Groupe Hospitalier Diaconesses - Croix Saint-Simon, 125 rue d'Avron, 75020, Paris, France.
出版信息
J Bone Jt Infect. 2021 Apr 1;6(5):131-134. doi: 10.5194/jbji-6-131-2021. eCollection 2021.
Abstract
We describe a 79-year-old man with spondylodiscitis and unknown pathogen, treated with cefazolin and rifampicin. He developed a massive digestive hemorrhage. Prothrombin time was prolonged with severe vitamin-K-dependent clotting-factor deficiency. Severe bleeding can occur during cefazolin and rifampicin use. This deficiency should be assessed before prescribing cefazolin-rifampicin and prothrombin time monitored.
摘要
我们描述了一名79岁患有脊椎椎间盘炎且病原体不明的男性患者，接受了头孢唑林和利福平治疗。他出现了大量消化道出血。凝血酶原时间延长，伴有严重的维生素K依赖凝血因子缺乏。在使用头孢唑林和利福平期间可能会发生严重出血。在开具头孢唑林-利福平处方前应评估这种缺乏情况，并监测凝血酶原时间。
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