头孢唑林和利福平治疗期间的凝血障碍：罕见但危险。
Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous.
作者信息
Kouki Ines, Montagner Clémence, Mauhin Wladimir, London Jonathan, Lazard Thierry, Grimbert Sylvie, Zeller Valérie, Lidove Olivier
机构信息
Service de Médecine Interne, Groupe Hospitalier Diaconesses - Croix Saint-Simon, 125 rue d'Avron, 75020, Paris, France.
Service de Réanimation, Groupe Hospitalier Diaconesses - Croix Saint-Simon, 125 rue d'Avron, 75020, Paris, France.
出版信息
J Bone Jt Infect. 2021 Apr 1;6(5):131-134. doi: 10.5194/jbji-6-131-2021. eCollection 2021.
Abstract
We describe a 79-year-old man with spondylodiscitis and unknown pathogen, treated with cefazolin and rifampicin. He developed a massive digestive hemorrhage. Prothrombin time was prolonged with severe vitamin-K-dependent clotting-factor deficiency. Severe bleeding can occur during cefazolin and rifampicin use. This deficiency should be assessed before prescribing cefazolin-rifampicin and prothrombin time monitored.
摘要
我们描述了一名79岁患有脊椎椎间盘炎且病原体不明的男性患者，接受了头孢唑林和利福平治疗。他出现了大量消化道出血。凝血酶原时间延长，伴有严重的维生素K依赖凝血因子缺乏。在使用头孢唑林和利福平期间可能会发生严重出血。在开具头孢唑林-利福平处方前应评估这种缺乏情况，并监测凝血酶原时间。
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本文引用的文献
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[Cefazolin and coagulation disorders: a case report].[头孢唑林与凝血障碍：一例报告]
Ann Biol Clin (Paris). 2018 Jan 1;76(1):104-106. doi: 10.1684/abc.2017.1314.
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Hypoprothrombinemia and severe perioperative haemorrhagic complications in cardiac surgery patients treated with high-dose cefazolin for infective endocarditis.心脏手术患者因感染性心内膜炎接受高剂量头孢唑林治疗后出现低凝血酶原血症和严重围手术期出血并发症。
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