School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Adv Sci (Weinh). 2021 Aug;8(15):e2100231. doi: 10.1002/advs.202100231. Epub 2021 Jun 3.
Brain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration of their signal sensitivity over time due to acute inflammation from insertion trauma and chronic inflammation caused by the foreign body reaction. To address this challenge, a lubricated surface is fabricated to minimize friction during insertion and avoid immunogenicity during neural signal recording. Reduced friction force leads to 86% less impulse on the brain tissue, and thus immediately increases the number of measured signal electrodes by 102% upon insertion. Furthermore, the signal measurable period increases from 8 to 16 weeks due to the prevention of gliosis. By significantly reducing insertion damage and the foreign body reaction, the lubricated immune-stealthy probe surface (LIPS) can maximize the longevity of implantable BMIs.
脑机接口（BMI）通过在较长时间内双向翻译神经信息，有望治疗神经疾病。然而，由于插入创伤引起的急性炎症和异物反应引起的慢性炎症，这些植入设备的寿命仍然有限。为了解决这一挑战，制造了一种润滑表面，以最大限度地减少插入过程中的摩擦，并避免在记录神经信号时产生免疫原性。摩擦力的减小导致对脑组织的冲击力减少 86%，因此在插入时可立即将可测量信号电极的数量增加 102%。此外，由于防止了神经胶质增生，可测量信号的周期从 8 周增加到 16 周。通过显著减少插入损伤和异物反应，润滑免疫隐身探头表面（LIPS）可以最大限度地延长植入 BMI 的使用寿命。
