IEEE Trans Biomed Circuits Syst. 2016 Dec;10(6):1068-1078. doi: 10.1109/TBCAS.2016.2514522. Epub 2016 Feb 26.
Simultaneous recordings of neural activity at large scale, in the long term and under bio-safety conditions, can provide essential data. These data can be used to advance the technology for brain-machine interfaces in clinical applications, and to understand brain function. For this purpose, we present a new multichannel neural recording system that can record up to 4096-channel (ch) electrocorticogram data by multiple connections of customized application-specific integrated circuits (ASICs). The ASIC includes 64-ch low-noise amplifiers, analog time-division multiplexers, and 12-bit successive approximation register ADCs. Recorded data sampled at a rate of 1 kS/s are multiplexed with time division via an integrated multiplex board, and in total 51.2 Mbps of raw data for 4096 ch are generated. This system has an ultra-wideband (UWB) wireless unit for transmitting the recorded neural signals. The ASICs, multiplex boards, and UWB transmitter unit are designed with the aim of implanting them. From preliminary experiments with a human body-equivalent liquid phantom, we confirmed 4096-ch UWB wireless data transmission at 128 Mbps for distances below 20 mm .
同时记录大规模、长期和生物安全条件下的神经活动，可以提供重要的数据。这些数据可用于推进脑机接口技术在临床应用中的发展，并帮助我们理解大脑功能。为此，我们提出了一种新的多通道神经记录系统，该系统可以通过多个定制专用集成电路（ASIC）的连接来记录多达 4096 通道的脑电数据。ASIC 包括 64 通道低噪声放大器、模拟时分复用器和 12 位逐次逼近寄存器 ADC。以 1 kS/s 的速率采样的记录数据通过集成的多路复用板进行时分复用，总共可以生成 51.2 Mbps 的 4096 通道原始数据。该系统具有用于传输记录神经信号的超宽带（UWB）无线单元。ASIC、多路复用板和 UWB 发射器单元的设计目的是将它们植入人体。通过与人体等效液体模型的初步实验，我们确认在 20mm 以下的距离内，以 128Mbps 的速率可以进行 4096 通道的 UWB 无线数据传输。
