Li Jingen, Liu Qian, Liu Defei, Wu Min, Tian Chaoguang
Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao. 2021 May 25;37(5):1637-1658. doi: 10.13345/j.cjb.200723.
Filamentous fungi are important industrial microorganisms that play important roles in the production of bio-based products such as organic acids, proteins and secondary metabolites. The development of metabolic engineering and its enabling techniques have greatly promoted the design, construction and application of filamentous fungal cell factories. This article systematically reviews the development of filamentous fungal cell factories constructed through metabolic engineering, and discusses the challenges and future perspectives for systems metabolic engineering of filamentous fungi.
丝状真菌是重要的工业微生物，在生产有机酸、蛋白质和次级代谢产物等生物基产品中发挥着重要作用。代谢工程及其相关技术的发展极大地推动了丝状真菌细胞工厂的设计、构建和应用。本文系统综述了通过代谢工程构建丝状真菌细胞工厂的发展情况，并探讨了丝状真菌系统代谢工程面临的挑战和未来前景。
