Southern Medical University, Guangzhou, Guangdong, China.
Department of Ophthalmology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Exp Eye Res. 2021 Aug;209:108626. doi: 10.1016/j.exer.2021.108626. Epub 2021 Jun 1.
Exosomes have diverse functions and rich content and are involved in intercellular communication, immune regulation, viral infection, tissue regeneration, and the occurrence, development and metastasis of tumours. Notably, various stem cell-derived exosomes are expected to become new therapeutic approaches for inflammatory diseases and tumours and have good clinical application prospects. However, few studies have examined exosomes in ophthalmic diseases. Therefore, based on the functions of exosomes, this paper summarizes progress in the possible use of exosomes as treatment for specific ophthalmic diseases, aiming to determine the pathogenesis of exosomes to achieve more effective clinical diagnosis and treatment of these diseases.
外泌体具有多种功能和丰富的内容，参与细胞间通讯、免疫调节、病毒感染、组织再生以及肿瘤的发生、发展和转移。值得注意的是，各种干细胞来源的外泌体有望成为炎症性疾病和肿瘤的新治疗方法，具有良好的临床应用前景。然而，关于外泌体在眼部疾病中的研究较少。因此，本文基于外泌体的功能，总结了外泌体作为特定眼科疾病治疗方法的可能用途，旨在确定外泌体的发病机制，以实现对这些疾病更有效的临床诊断和治疗。
