Fasina Yewande O, Obanla Temitayo O, Ferket Peter R, Shah Devendra H
Department of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411 USA.
Department of Animal Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411 USA.
Poult Sci. 2021 Jul;100(7):101134. doi: 10.1016/j.psj.2021.101134. Epub 2021 Mar 15.
Spray-dried plasma (SDP) contains immunoglobulins and glycoproteins that possess antibacterial properties. Two floor-pen trials were conducted to determine the efficacy of dietary SDP and bacitracin methylene disalicylate (BMD) antibiotic in reducing intestinal colonization by Salmonella Enteritidis (SE) in broiler chickens. Experiment 1 was a 2-wk, 3 × 2 factorial design consisting of 6 treatments. Treatment CON consisted of chicks fed unmedicated corn-soybean meal (SBM) basal without SDP. Treatment BMD consisted of chicks given unmedicated corn-SBM basal into which BMD was added at 0.055g/kg diet. Treatment SDP consisted of chicks given unmedicated corn-SBM basal into which SDP was added at 30g/kg diet. Treatments CON-SE, BMD-SE, and SDP-SE consisted of chicks that were given diets similar to CON, BMD, and SDP, respectively, and were each inoculated with 7.46 × 10 CFU SE /mL at 1 day of age. Experiment 2 was a 42-day trial that was similar to Experiment 1 in design, except that chicks were placed on fresh clean litter. On d 3, 7, 14, and 28 post-challenge (PC), ceca SE concentration was enumerated on xylose lysine tergitol-4 (XLT4) agar. Body weight gain (BWG) and feed conversion ratio (FCR) were also recorded. Results for d 3 showed that BMD- and SDP-fed chicks had similar (P > 0.05) cecal SE (3.39 log CFU / g and 3.58 log CFU / g, respectively), but these levels were lower (P < 0.05) than that of CON-fed chicks (5.68 log CFU / g). A similar trend was observed on d 7 and 14 PC. The BMD- and SDP-fed chicks also had higher BWG and FCR (P < 0.05) when compared with CON-fed chicks up to d 14. Thereafter, only BMD treatment sustained this growth-promoting effect till d 42 in SE-challenged birds. In conclusion, BMD and SDP showed similar efficacy in reducing cecal Salmonella and in mitigating consequent growth-depressing effect(s) in broiler chicks up to 2 wk of age.
喷雾干燥血浆（SDP）含有具有抗菌特性的免疫球蛋白和糖蛋白。进行了两项地面平养试验，以确定日粮中添加SDP和杆菌肽亚甲基二水杨酸酯（BMD）抗生素对减少肉鸡肠炎沙门氏菌（SE）肠道定植的效果。试验1为为期2周的3×2析因设计，包括6种处理。处理组CON由饲喂不含SDP的未添加药物的玉米-豆粕（SBM）基础日粮的雏鸡组成。处理组BMD由饲喂未添加药物的玉米-SBM基础日粮且在日粮中添加0.055g/kg BMD的雏鸡组成。处理组SDP由饲喂未添加药物的玉米-SBM基础日粮且在日粮中添加30g/kg SDP的雏鸡组成。处理组CON-SE、BMD-SE和SDP-SE分别由饲喂与CON、BMD和SDP相似日粮且在1日龄时每只接种7.46×10 CFU SE/mL的雏鸡组成。试验2为为期42天的试验，设计与试验1相似，不同之处在于雏鸡放置在新鲜干净的垫料上。在攻毒后第3、7、14和28天（PC），在木糖赖氨酸吐温-4（XLT4）琼脂平板上计数盲肠SE浓度。还记录了体重增加（BWG）和饲料转化率（FCR）。第3天的结果表明，饲喂BMD和SDP的雏鸡盲肠SE浓度相似（P>0.05）（分别为3.39 log CFU/g和3.58 log CFU/g），但这些水平低于饲喂CON的雏鸡（5.68 log CFU/g）（P<0.05）。在攻毒后第7天和14天观察到类似趋势。在第14天之前，与饲喂CON的雏鸡相比，饲喂BMD和SDP的雏鸡也有更高的BWG和FCR（P<0.05）。此后，在感染SE的鸡中，只有BMD处理在第42天之前持续保持这种促生长作用。总之，在减少盲肠沙门氏菌以及减轻对2周龄以内肉鸡随后生长抑制作用方面，BMD和SDP显示出相似的效果。
