Laboratory for Traumatic Stress Studies, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
People's Hospital of Deyang City, Deyang, Sichuan, China.
J Psychiatr Res. 2021 Aug;140:30-34. doi: 10.1016/j.jpsychires.2021.05.061. Epub 2021 May 27.
Anhedonia is common in individuals with traumatic experience. Anhedonia symptoms play an important role in posttraumatic psychopathology, and are related to various adverse outcomes. The current study is a preliminary neuroimaging study of the neural correlates of posttraumatic anhedonia symptoms. Resting-state fMRI data were acquired from 88 Chinese earthquake survivors. Whole brain analyses and exploratory ROI-to-ROI analyses were performed to examine the relationship between posttraumatic anhedonia symptoms and resting-state functional connectivity (rsFC) of reward-related subcortical nucleus including nucleus accumbens and ventral pallidum. The rsFC between left ventral pallidum and areas of bilateral posterior cingulate cortex (PCC) and precuneus cortex were found lower in the high posttraumatic anhedonia group, after controlling for sex, age and other posttraumatic stress symptoms. The rsFC between left ventral pallidum and PCC and the rsFC between left ventral pallidum and lateral parietal cortex were significantly lower in the high anhedonia group. Our findings suggest that decreased functional connectivity between the ventral pallidum and the brain default mode network (DMN) regions could be the neural correlates of posttraumatic anhedonia symptoms.
创伤后快感缺失在经历过创伤的个体中很常见。快感缺失症状在创伤后精神病理学中起着重要作用，并与各种不良后果相关。本研究是对创伤后快感缺失症状的神经相关性进行的初步神经影像学研究。从 88 名中国地震幸存者中获取了静息态 fMRI 数据。进行了全脑分析和探索性 ROI-ROI 分析，以研究创伤后快感缺失症状与包括伏隔核和腹侧苍白球在内的奖赏相关皮质下核团的静息态功能连接（rsFC）之间的关系。在控制了性别、年龄和其他创伤后应激症状后，发现在高创伤后快感缺失组中，左侧腹侧苍白球与双侧后扣带回皮质（PCC）和楔前叶区域之间的 rsFC 较低。在高快感缺失组中，左侧腹侧苍白球与 PCC 之间的 rsFC 和左侧腹侧苍白球与外侧顶叶皮质之间的 rsFC 明显较低。我们的研究结果表明，腹侧苍白球与大脑默认模式网络（DMN）区域之间的功能连接减少可能是创伤后快感缺失症状的神经相关性。
