原发性干燥综合征患者自然杀伤细胞细胞毒性因子释放受损。
Impaired release of natural killer cytotoxic factor in patients with primary Sjögren's syndrome.
作者信息
Pedersen B K, Oxholm P
机构信息
Laboratory of Medical Immunology, Rigshospitalet, Copenhagen, Denmark.
出版信息
Clin Exp Immunol. 1988 May;72(2):299-302.
The impaired natural killer (NK) cell activity against K562 target cells of patients with primary Sjögren's syndrome (primary SS) was re-examined in a 2-year follow-up study of 10 patients and 10 normal controls. The ability of blood mononuclear cells (BMNC) to form effector/target cell conjugates and to release NK cytotoxic factor (NKCF) were studied. NK cell activity of the patients was unchanged low (P less than 0.01) compared with the controls. The number of effector/target cell conjugates did not differ between patients and controls, whereas NKCF-release from interferon-stimulated BMNC was significantly (P less than 0.01) reduced in the patients with primary SS and positively correlated to the reduced NK cell activity (r = 0.85, P = 0.0002). The permanently low NK cell activity of patients with primary SS appears therefore, at least in part, to be due to an impaired release of NKCF and not to a defective ability of effector cells to recognize and/or adhere to target cells.
在一项针对10例原发性干燥综合征（原发性SS）患者和10名正常对照者的为期2年的随访研究中，对原发性SS患者针对K562靶细胞的自然杀伤（NK）细胞活性受损情况进行了重新检查。研究了血液单核细胞（BMNC）形成效应细胞/靶细胞结合物以及释放NK细胞毒性因子（NKCF）的能力。与对照组相比，患者的NK细胞活性持续较低（P<0.01）。患者和对照组之间效应细胞/靶细胞结合物的数量没有差异，而原发性SS患者经干扰素刺激的BMNC释放NKCF显著减少（P<0.01），且与NK细胞活性降低呈正相关（r = 0.85，P = 0.0002）。因此，原发性SS患者NK细胞活性持续较低至少部分是由于NKCF释放受损，而非效应细胞识别和/或黏附靶细胞的能力存在缺陷。
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