白细胞介素2增强原发性干燥综合征患者存在缺陷的自然杀伤细胞活性。
Interleukin 2 augmentation of the defective natural killer cell activity in patients with primary Sjögren's syndrome.
作者信息
Pedersen B K, Oxholm P, Manthorpe R, Andersen V
出版信息
Clin Exp Immunol. 1986 Jan;63(1):1-7.
Natural Killer (NK) cell activity against K562 target cells was measured in 21 female patients with primary Sjögren's syndrome (primary SS) and in 20 female normal controls matched for age. The in vitro effect of alpha-interferon (IF) and interleukin 2 (IL-2) on NK cell activity was examined and the percentage of large granular lymphocytes (LGL) in blood was measured. Median baseline NK cell activity in primary SS was 15.4% versus 24.4% in the controls (P less than 0.05). Median IF-enhanced NK cell activity in the SS group was 35.5% versus 49.6% in the controls (P less than 0.02). IL-2-enhanced NK cell activity was 35.5% versus 37.6% in the controls (n.s.) The proportion of LGL did not differ in the two groups. Median LGL/lymphocytes was 4.0% in the primary SS patients versus 4.5% in the controls (n.s.). We conclude that the defective NK cell activity in patients with primary SS is functional, as the number of LGL is normal. Further the NK cell activity off SS was restored by IL-2.
对21例原发性干燥综合征（原发性SS）女性患者及20名年龄匹配的正常女性对照者，检测了其针对K562靶细胞的自然杀伤（NK）细胞活性。研究了α干扰素（IF）和白细胞介素2（IL-2）对NK细胞活性的体外作用，并测定了血液中大颗粒淋巴细胞（LGL）的百分比。原发性SS患者的基线NK细胞活性中位数为15.4%，而对照组为24.4%（P<0.05）。SS组中IF增强的NK细胞活性中位数为35.5%，而对照组为49.6%（P<0.02）。IL-2增强的NK细胞活性在对照组中为37.6%，在SS组中为35.5%（无统计学差异）。两组的LGL比例无差异。原发性SS患者的LGL/淋巴细胞中位数为4.0%，对照组为4.5%（无统计学差异）。我们得出结论，原发性SS患者NK细胞活性缺陷是功能性的，因为LGL数量正常。此外，SS患者的NK细胞活性可通过IL-2恢复。
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