Huang Xiaoyu, Ge Yang, Yang Bina, Han Qi, Zhou Wen, Liang Jingou, Li Mingyun, Peng Xian, Ren Biao, Yang Bangcheng, Weir Michael D, Guo Qiang, Wang Haohao, Zhou Xinxuan, Lu Xugang, Oates Thomas W, Xu Hockin H K, Deng Dongmei, Zhou Xuedong, Cheng Lei
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.
Department of Operative Dentistry and Endodontics, West China School of Stomatology, Sichuan University, Chengdu, 610041, China.
Bioact Mater. 2021 May 15;6(12):4568-4579. doi: 10.1016/j.bioactmat.2021.04.041. eCollection 2021 Dec.
Peri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials. The method shows good osteogenic properties but weak antibacterial effect. Therefore, we developed combined strategies to combat severe peri-implantitis, which included the use of a novel compound, PD, comprising dendrimers poly(amidoamine) (PAMAM) loading dimethylaminododecyl methacrylate (DMADDM) as well as MAO treatment. Here, we explored the chemical properties of the novel compound PD, and proved that this compound was successfully synthesized, with the loading efficiency and encapsulation efficiency of 23.91% and 31.42%, respectively. We further report the two-stage double benefits capability of PD + MAO: (1) in the first stage, PD + MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both and ; (2) in the second stage, PD + MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis . This study first reports the two-staged, double benefits of PD + MAO, and demonstrates its potential in clinical applications for inhibiting peri-implantitis, especially in patients with severe infection risk.
种植体周围炎是目前导致种植失败的一个主要问题。因此，早期抗感染以及随后促进骨整合是解决这一问题的两个主要关键因素。微弧氧化（MAO）处理是在金属材料表面形成氧化膜的一种方法。该方法显示出良好的成骨特性，但抗菌效果较弱。因此，我们开发了联合策略来对抗严重的种植体周围炎，其中包括使用一种新型化合物PD，它由负载甲基丙烯酸十二烷基二甲胺（DMADDM）的树枝状聚酰胺胺（PAMAM）组成，以及进行MAO处理。在此，我们探究了新型化合物PD的化学性质，并证明该化合物已成功合成，负载效率和包封率分别为23.91%和31.42%。我们进一步报道了PD + MAO的两阶段双重益处能力：（1）在第一阶段，PD + MAO可通过在种植手术后高度感染的第一阶段释放DMADDM来减少生物膜的附着和形成；（2）在第二阶段，PD + MAO在种植体周围炎大鼠模型中显示出强大的抗感染和骨传导特性。本研究首次报道了PD + MAO的两阶段双重益处，并证明了其在临床应用中抑制种植体周围炎的潜力，尤其是对于有严重感染风险的患者。
