ZJ316 Attenuates -Induced Gastritis in C57BL/6 Mice.

is a highly prevalent human-specific pathogen that causes various gastric diseases. In the present study, ZJ316, which could survive well in simulated gastrointestinal conditions, was found to have significant anti- ability. Animal assays revealed that ZJ316 had preventive and therapeutic effects on -induced gastritis. ZJ316 significantly decreased interferon γ (IFN-γ) and interleukin 6 (IL-6) levels, increased the IL-10 level, and repaired mucosal damage. Moreover, 16S rRNA gene sequencing revealed that the relative abundance of could be significantly reduced by ZJ316 administration. Members of the families Dehalobacteriaceae and Geodermatophilaceae were more prevalent in the prevention group, while Lactobacillaceae and Actinomycetaceae were more prevalent in the treatment group. These results indicate that ZJ316 serves as a potential candidate for the prevention and treatment of -induced gastritis by regulating the gastric microbiota and reducing mucosal inflammation.