Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Organic Chemistry, Faculty of Chemistry, Complutense University of Madrid (UCM), Madrid, Spain.
Photochem Photobiol. 2021 Nov;97(6):1266-1277. doi: 10.1111/php.13461. Epub 2021 Jul 8.
This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH-aPDI). This review should be of interest to photochemists, photobiologists and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH-aPDI.
这篇综述描述了纳米粒子和染料在抗菌光动力灭活（aPDI）背景下在细菌生物膜中的扩散。aPDI 需要光敏剂（Sens）扩散到生物膜中，然后用光激活氧气以产生杀死微生物的活性氧（ROS）。分子在生物膜中的扩散已经被长期研究，而本综述旨在在生物膜中的扩散和 ROS 之间建立逻辑联系，这种结合导致了当前的 aPDI 和超疏水 aPDI（SH-aPDI）状态。本综述应该对光化学家、光生物学家和材料及抗菌科学领域的研究人员感兴趣，因为它将传统的 aPDI 与新兴的 SH-aPDI 主题联系起来。
