Gielen Anke H C, Samarska Iryna, Den Dulk Marcel, Beckervordersandforth Jan, Dejong Kees H C, Bouwense Stefan A W, Dewulf Maxime
Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands.
Acta Chir Belg. 2023 Apr;123(2):178-184. doi: 10.1080/00015458.2021.1940443. Epub 2021 Jun 21.
The presence of osteoclast-like giant cells (OGC) in hepatocellular carcinoma (HCC) is rare and literature on this topic is scarce. In this article, we report on a case of a 77-year-old male patient with HCC with OGC and provide an overview of the current literature.
We conducted a systematic search to find all available literature on OGC in HCC. The electronic databases PubMed, Web of Science, Embase and CENTRAL were searched from inception until October 2020.
Thirteen articles on this topic were identified and were included in this review. Data on 14 patients were available, described in twelve case reports, one patient in a patient series and the present case. Median age of included patients was 68 years. Two patients underwent neoadjuvant therapy prior to surgery. Of the 14 cases, eight tumours with OGC arose in a cirrhotic liver. Oncological outcome in this series was unfavourable, even after surgical resection, with a median disease-free survival of 75 d.
The presence of OGC in HCC is rare. Current literature is scarce, and suggests an unfavourable outcome in regard to overall survival of HCC.
肝细胞癌（HCC）中破骨细胞样巨细胞（OGC）的存在较为罕见，关于这一主题的文献也很匮乏。在本文中，我们报告了一例77岁男性肝细胞癌伴破骨细胞样巨细胞的病例，并对当前文献进行综述。
我们进行了系统检索，以查找所有关于肝细胞癌中破骨细胞样巨细胞的可用文献。从数据库建立到2020年10月，检索了电子数据库PubMed、科学网、Embase和CENTRAL。
共识别出13篇关于该主题的文章并纳入本综述。获得了14例患者的数据，其中12例为病例报告，1例来自患者系列研究，还有本病例。纳入患者的中位年龄为68岁。2例患者在手术前接受了新辅助治疗。在这14例病例中，8例伴有破骨细胞样巨细胞的肿瘤发生于肝硬化肝脏。该系列患者的肿瘤学结局不佳，即使在手术切除后也是如此，无病生存期的中位数为75天。
肝细胞癌中破骨细胞样巨细胞的存在较为罕见。当前文献较少，提示肝细胞癌患者的总生存期结局不佳。
