He Xi-Fan, Wang Hui, Tian Ye, Zhang Te, Qiu Zhi-Peng, Cui Xiao-Jiao, Zhou Jing-Sha, Yan Xin-Lan, Wu Yi-Wei, Pan Yi-Sha, Ning Yang-Bo, Chen Lin, Zhang Kun-Lun, Zhao Wei-Hao, Sharma David, Tan Xiao-Dan, Zhang Michael Bo
Department of Oral and Maxillofacial Surgery, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, People's Republic of China.
Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Biol Trace Elem Res. 2023 Feb;201(2):677-682. doi: 10.1007/s12011-022-03210-w. Epub 2022 Mar 24.
Dental calculus is a potential material that can be used for assessing chronic exposure to trace heavy metals in oral cavity as it is a long-term reservoir. The aim of this study was to investigate the correlation between dental calculus copper levels and risk of oral submucous fibrosis (OSF) due to chewing dried areca-nut quids in Mainland China. This study included 34 OSF (grade 1) sufferers with dried areca-nut quids chewing as the patient group and 23 healthy individuals without areca-nut chewing as the control group. The dental calculus sample was obtained from all 57 participants and evaluated by inductively coupled plasma mass spectrometry (ICP-MS) for dental calculus level of copper. This work revealed that the mean copper level of dental calculus was significantly higher in OSF (grade 1) sufferers with areca-nut chewing than those in healthy individuals without areca-nut chewing (p < 0.001). This work provided an evidence to support that there may be a positive correlation between elevated levels of copper in dental calculus caused by chewing dried areca-nut quids and an increased risk of developing OSF in Mainland China.
牙结石是一种潜在的材料，由于它是一种长期的储存库，可用于评估口腔中痕量重金属的慢性暴露情况。本研究的目的是调查中国大陆地区牙结石铜含量与嚼食干槟榔块导致口腔黏膜下纤维化（OSF）风险之间的相关性。本研究纳入了34名嚼食干槟榔块的OSF（1级）患者作为患者组，以及23名不嚼食槟榔的健康个体作为对照组。从所有57名参与者中获取牙结石样本，并通过电感耦合等离子体质谱法（ICP-MS）评估牙结石中的铜含量。这项研究表明，嚼食槟榔的OSF（1级）患者牙结石中的平均铜含量显著高于不嚼食槟榔的健康个体（p < 0.001）。这项研究为支持以下观点提供了证据：在中国大陆，嚼食干槟榔块导致牙结石中铜含量升高与患OSF风险增加之间可能存在正相关。
