Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, California, USA.
Division of Plastic Surgery, City of Hope National Medical Center, Duarte, California, USA.
Adv Wound Care (New Rochelle). 2022 Aug;11(8):399-418. doi: 10.1089/wound.2021.0033. Epub 2021 Aug 27.
Secondary lymphedema is a debilitating disease caused by lymphatic dysfunction characterized by chronic swelling, dysregulated inflammation, disfigurement, and compromised wound healing. Since there is no effective cure, animal model systems that support basic science research into the mechanisms of secondary lymphedema are critical to advancing the field. Over the last decade, lymphatic research has led to the improvement of existing animal lymphedema models and the establishment of new models. Although an ideal model does not exist, it is important to consider the strengths and limitations of currently available options. In a systematic review adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we present recent developments in the field of animal lymphedema models and provide a concise comparison of ease, cost, reliability, and clinical translatability. The incidence of secondary lymphedema is increasing, and there is no gold standard of treatment or cure for secondary lymphedema. As we iterate and create animal models that more closely characterize human lymphedema, we can achieve a deeper understanding of the pathophysiology and potentially develop effective therapeutics for patients.
继发性淋巴水肿是一种由淋巴功能障碍引起的使人虚弱的疾病，其特征为慢性肿胀、失调的炎症、畸形和受损的伤口愈合。由于目前尚无有效的治疗方法，支持继发性淋巴水肿机制基础科学研究的动物模型系统对于推动该领域的发展至关重要。在过去的十年中，淋巴研究导致了现有动物淋巴水肿模型的改进和新模型的建立。虽然不存在理想的模型，但考虑当前可用选择的优缺点很重要。在一项遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南的系统评价中，我们展示了动物淋巴水肿模型领域的最新进展，并对其便利性、成本、可靠性和临床转化性进行了简明比较。继发性淋巴水肿的发病率正在上升，而继发性淋巴水肿的治疗或治愈方法尚无金标准。随着我们反复和创建更能描绘人类淋巴水肿的动物模型，我们可以更深入地了解病理生理学，并有可能为患者开发有效的治疗方法。
