Transplantation Center, Korea University Anam Hospital, Seoul, Korea.
Department of Critical Care Medicine & Surgery, Ewha Womans University Mokdong Hospital, Seoul, Korea.
J Korean Med Sci. 2021 Jun 14;36(23):e171. doi: 10.3346/jkms.2021.36.e171.
In February 2018, the Withdrawal of the Life-sustaining Treatment (WLST) Decision Act was legalized in Korea. Donation after circulatory death (DCD) after WLST was classified as DCD category III. We report the first case of successful organ donation after WLST in Korea. A 52-year-old male who experienced cerebral hemorrhage was a potential brain-dead donor with donation consent. During the first brain death examination, Babinski reflex was present, which disappeared two days later. Then, electroencephalography was performed five times at intervals of 2 to 3 days, according to the recommendation of a neurologist. The patient was transferred to the OR at 19:30 July 3, 2020. At 20:00, an intensive care unit specialist performed extubation and discontinued vasopressors. Oxygen saturation fell to < 70% in 1 minute, which signaled the beginning of functional warm ischemia. At 20:15, asystole was confirmed; after 5 minutes of "no-touch time," circulatory death was declared. Organ procurement surgery was initiated, with surgeons performing the recipient surgery ready in the adjacent OR. Through the first successful DCD case, we expected that DCD will be actively implemented in Korea, saving the lives of patient waiting for transplantation and resolving the imbalance between organ receipt and donation.
2018 年 2 月,韩国将《终止维持生命治疗法》(WLST)合法化。在 WLST 后进行的循环死亡后捐献(DCD)被归类为 DCD 第三类。我们报告了韩国首例 WLST 后成功进行器官捐献的病例。一名 52 岁男性因脑出血成为潜在的脑死亡供者,并已获得捐献同意。在首次脑死亡检查时,存在巴宾斯基反射,两天后消失。随后,根据神经科医生的建议,每隔 2-3 天进行 5 次脑电图检查。患者于 2020 年 7 月 3 日 19:30 转入手术室。20:00,一名重症监护专家进行气管插管拔管,并停止使用升压药。1 分钟内血氧饱和度降至<70%,这标志着功能性热缺血的开始。20:15 出现心脏停搏;在“无接触时间”5 分钟后,宣告循环死亡。器官获取手术随即开始,手术医生在相邻的手术室准备进行受体手术。通过首例成功的 DCD 病例,我们预计 DCD 将在韩国得到积极实施,挽救等待移植的患者的生命,并解决器官接受和捐献之间的不平衡问题。