Chen Ai-Qun, Gao Xiao-Fei, Wang Zhi-Mei, Wang Feng, Luo Shuai, Gu Yue, Zhang Jun-Jie, Chen Shao-Liang
Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Department of Cardiology, Nanjing Heart Centre, Nanjing, China.
Front Cardiovasc Med. 2021 May 31;8:691548. doi: 10.3389/fcvm.2021.691548. eCollection 2021.
Exosomes, with an diameter of 30~150 nm, could be released from almost all types of cells, which contain diverse effective constituent, such as RNAs, proteins, lipids, and so on. In recent years, exosomes have been verified to play an important role in mechanism, diagnosis, treatment, and prognosis of cardiovascular disease, especially coronary artery disease (CAD). Moreover, it has also been shown that exosomes derived from different cell types have various biological functions based on the cell stimulation and microenvironment. However, therapeutic exosomes are currently far away from clinical translation, despite it is full of hope. In this review, we summarize an update of the recent studies and systematic knowledge of therapeutic exosomes in atherosclerosis, myocardial infarction, and in-stent restenosis, which might provide a novel insight into the treatment of CAD and promote the potential clinical application of therapeutic exosomes.
外泌体直径为30~150纳米，几乎可从所有类型的细胞中释放出来，其包含多种有效成分，如RNA、蛋白质、脂质等。近年来，外泌体已被证实可在心血管疾病尤其是冠状动脉疾病（CAD）的发病机制、诊断、治疗及预后中发挥重要作用。此外，研究还表明，源自不同细胞类型的外泌体基于细胞刺激和微环境具有多种生物学功能。然而，尽管治疗性外泌体充满希望，但目前距离临床应用仍有很大差距。在本综述中，我们总结了治疗性外泌体在动脉粥样硬化、心肌梗死和支架内再狭窄方面的最新研究及系统知识，这可能为CAD的治疗提供新的见解，并促进治疗性外泌体的潜在临床应用。
