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肯尼亚医院收治无腹泻儿童脱水的流行情况和液体管理:一项多中心观察性研究。

Prevalence and fluid management of dehydration in children without diarrhoea admitted to Kenyan hospitals: a multisite observational study.

机构信息

Health Services Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya

Health Services Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

出版信息

BMJ Open. 2021 Jun 18;11(6):e042079. doi: 10.1136/bmjopen-2020-042079.

Abstract

OBJECTIVES

To examine the prevalence of dehydration without diarrhoea among admitted children aged 1-59 months and to describe fluid management practices in such cases.

DESIGN

A multisite observational study that used routine in-patient data collected prospectively between October 2013 and December 2018.

SETTINGS

Study conducted in 13 county referral hospitals in Kenya.

PARTICIPANTS

Children aged 1-59 months with admission or discharge diagnosis of dehydration but had no diarrhoea as a symptom or diagnosis. Children aged <28 days and those with severe acute malnutrition were excluded.

RESULTS

The prevalence of dehydration in children without diarrhoea was 3.0% (2019/68 204) and comprised 15.9% (2019/12 702) of all dehydration cases. Only 55.8% (1127/2019) of affected children received either oral or intravenous fluid therapy. Where fluid treatment was given, the volumes, type of fluid, duration of fluid therapy and route of administration were similar to those used in the treatment of dehydration secondary to diarrhoea. Pneumonia (1021/2019, 50.6%) and malaria (715/2019, 35.4%) were the two most common comorbid diagnoses. Overall case fatality in the study population was 12.9% (260/2019).

CONCLUSION

Sixteen per cent of children hospitalised with dehydration do not have diarrhoea but other common illnesses. Two-fifths do not receive fluid therapy; a regimen similar to that used in diarrhoeal cases is used in cases where fluid is administered. Efforts to promote compliance with guidance in routine clinical settings should recognise special circumstances where guidelines do not apply, and further studies on appropriate management for dehydration in the absence of diarrhoea are required.

摘要

目的

调查 1-59 月龄住院患儿中无腹泻脱水的流行情况,并描述此类病例的液体管理方法。

设计

一项多中心观察性研究,使用 2013 年 10 月至 2018 年 12 月期间前瞻性收集的常规住院数据。

地点

在肯尼亚的 13 家县转诊医院进行的研究。

参与者

纳入年龄 1-59 个月,入院或出院诊断为脱水但无腹泻症状或诊断的患儿。年龄<28 天和严重急性营养不良的患儿被排除在外。

结果

无腹泻脱水患儿的患病率为 3.0%(2019 年/68204 例),占所有脱水病例的 15.9%(2019 年/12702 例)。仅有 55.8%(2019 年/1127 例)受影响的患儿接受了口服或静脉补液治疗。在给予液体治疗的情况下,所使用的液体量、类型、液体治疗持续时间和给药途径与治疗腹泻引起的脱水相似。最常见的两种合并诊断是肺炎(1021/2019,50.6%)和疟疾(715/2019,35.4%)。研究人群的总病死率为 12.9%(260/2019)。

结论

16%的因脱水住院的患儿没有腹泻,但有其他常见疾病。五分之二的患儿没有接受液体治疗;在给予液体的病例中,使用了类似于治疗腹泻病例的方案。在常规临床环境中促进指南依从性的努力应认识到指南不适用的特殊情况,需要进一步研究无腹泻脱水的适当治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b12/8215254/6bb82a7bb4ba/bmjopen-2020-042079f01.jpg

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