Sun Kai, Zhang Xue-de, Liu Xiao-Yang, Lu Pei
Department of Oncology, Liuzhou People's Hospital, Liuzhou, China.
Department of Hematology and Oncology, Beilun District People's Hospital, Ningbo, China.
Front Mol Biosci. 2021 Jun 2;8:625731. doi: 10.3389/fmolb.2021.625731. eCollection 2021.
Yes-associated protein-1 (YAP1) is an important effector of the Hippo pathway and has crosstalk with other cancer signaling pathways. It induces an immunosuppressive tumor microenvironment by activating pathways in several cellular components. However, the mechanisms by which it drives immune infiltration in pancreatic cancer remain poorly understood. We analyzed the expression of YAP1 as well as its prognostic value and correlations with immune infiltrates in various cancers, with a focus on pancreatic cancer. In particular, using the Oncomine database and Gene Expression Profiling Interactive Analysis (GEPIA) database, we found that YAP1 is differentially expressed between tumor tissues and control tissues in a number of cancers and in particular, is elevated in pancreatic cancer. Using the Kaplan-Meier plotter, GEPIA, and Long-term Outcome and Gene Expression Profiling database of pan-cancers (LOGpc), we further established the prognostic value of YAP1. We found that YAP1 expression was significantly related to outcomes in multiple types of cancer based on data from The Cancer Genome Atlas, particularly in pancreatic cancer. Correlations between YAP1 and immune cell infiltration and immune cell marker expression were examined using Tumor Immune Estimation Resource and GEPIA. High expression levels of YAP1 were significantly associated with a variety of immune markers and immune cell subsets in pancreatic cancer. These results suggest that YAP1 is correlated with patient outcomes and tumor immune cell infiltration in multiple cancer types and is a valuable prognostic biomarker in pancreatic cancer.
Yes相关蛋白1（YAP1）是Hippo信号通路的重要效应分子，并且与其他癌症信号通路存在交互作用。它通过激活多个细胞成分中的信号通路来诱导免疫抑制性肿瘤微环境。然而，其驱动胰腺癌免疫浸润的机制仍知之甚少。我们分析了YAP1的表达及其预后价值，以及它与各种癌症中免疫浸润的相关性，重点是胰腺癌。具体而言，通过使用Oncomine数据库和基因表达谱交互式分析（GEPIA）数据库，我们发现YAP1在多种癌症的肿瘤组织和对照组织之间存在差异表达，特别是在胰腺癌中表达升高。利用Kaplan-Meier绘图工具、GEPIA以及泛癌长期结局与基因表达谱数据库（LOGpc），我们进一步确定了YAP1的预后价值。基于癌症基因组图谱的数据，我们发现YAP1表达与多种癌症类型的预后显著相关，尤其是在胰腺癌中。使用肿瘤免疫估计资源和GEPIA检测了YAP1与免疫细胞浸润及免疫细胞标志物表达之间的相关性。YAP1的高表达水平与胰腺癌中的多种免疫标志物和免疫细胞亚群显著相关。这些结果表明，YAP1与多种癌症类型的患者预后和肿瘤免疫细胞浸润相关，并且是胰腺癌中有价值的预后生物标志物。
