Rahalkar Apurva, Kumathalli Kanteshwari, Kumar Rajesh
Department of Periodontics, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, India.
J Indian Soc Periodontol. 2021 May-Jun;25(3):197-202. doi: 10.4103/jisp.jisp_158_20. Epub 2021 May 3.
The aim of our study is to assess the effectiveness of Curcumin and Tulsi in the control of periodontal parameters when delivered in the form of local drug delivery (LDD) agents.
Curenext gel and Tulsi gel were used as the two LDD agent. A split mouth randomized clinical trial was carried out in 15 patients. Three sites in different quadrants were assigned treatment modality of scaling and root planing (SRP) alone, SRP with LDD of curcumin and SRP with LDD of Tulsi extract, respectively. Clinical parameters Probing Pocket Depth, Clinical Attachment Level, Plaque Index, Gingival Index, and modified Sulcus Bleeding Index were recorded and subgingival plaque sample collected for N-benzoyl-L-arginine-p-nitroanilide (BAPNA) assay on baseline followed by LDD with extracts in the assigned group. The parameters were recorded at baseline and on 30 day postoperatively. Unpaired and Paired-'t' test were used for intergroup and intragroup comparison of recorded clinical and microbiological parameters.
All the treatment modalities showed statistically significant reduction in clinical and microbiological parameters on intragroup comparison. Intergroup comparison showed statistically significant reduction in Plaque Index in curcumin group and BAPNA assay in Tulsi group when compared to SRP.
Both the herbs were effective in improving periodontal parameters and may develop as an alternative to currently used LDD agents in near future.
我们研究的目的是评估姜黄素和罗勒以局部给药（LDD）制剂形式递送时对控制牙周参数的有效性。
将Curenext凝胶和罗勒凝胶用作两种LDD制剂。对15名患者进行了一项双侧随机临床试验。分别在不同象限的三个部位分配了单独的龈下刮治术和根面平整术（SRP）、姜黄素LDD联合SRP以及罗勒提取物LDD联合SRP的治疗方式。记录临床参数探诊深度、临床附着水平、菌斑指数、牙龈指数和改良龈沟出血指数，并在基线时收集龈下菌斑样本用于N-苯甲酰-L-精氨酸对硝基苯胺（BAPNA）测定，随后在指定组中用提取物进行LDD。在基线和术后30天记录参数。使用不成对和配对“t”检验对记录的临床和微生物学参数进行组间和组内比较。
所有治疗方式在组内比较时，临床和微生物学参数均显示出统计学上的显著降低。组间比较显示，与SRP相比，姜黄素组的菌斑指数和罗勒组的BAPNA测定在统计学上有显著降低。
这两种草药在改善牙周参数方面均有效，并且在不久的将来可能发展成为当前使用的LDD制剂的替代品。
