Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Tomatebodavägen 18A, 10th floor17165 Solna, Stockholm, Sweden.
Centro Medicina dell'Invecchiamento, Fondazione Policlinico "A. Gemelli" IRCCS and Università Cattolica del Sacro Cuore, Roma, Italy.
Aging Clin Exp Res. 2021 Aug;33(8):2361-2365. doi: 10.1007/s40520-021-01914-y. Epub 2021 Jun 24.
Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated.
A random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values ≥ 1.5.
Six pairs of diseases exhibited O/E values ≥ 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity.
In those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2.
大多数与 COVID-19 相关的死亡发生在患有合并症的老年人中。尚未研究与 COVID-19 死亡相关的特定合并症模式。
本研究纳入了 2020 年 2 月至 12 月期间在意大利因 COVID-19 住院死亡的 6085 名个体的随机样本。计算了疾病对的观察到的与预期（O/E）比值，并使用逻辑回归模型来确定 O/E 值≥1.5 的疾病对之间的关联。
有 6 对疾病的 O/E 值≥1.5，且在粗分析和调整分析中具有统计学显著更高的共病发生几率：（1）缺血性心脏病和心房颤动，（2）心房颤动和心力衰竭，（3）心房颤动和中风，（4）心力衰竭和 COPD，（5）中风和痴呆，以及（6）2 型糖尿病和肥胖症。
在意大利因 COVID-19 住院死亡的患者中，由多种心肺、代谢和神经精神疾病组成的疾病组合比预期更频繁地发生。这一发现表明需要研究这些临床特征在感染 SARS-CoV-2 的个体死亡事件链中的可能作用。
