Chi Xuepeng, Liu Zhenguo, Wang Hongfang, Wang Ying, Xu Baohua, Wei Wei
College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai' an, 271018, Shandong, China.
Biol Trace Elem Res. 2022 Apr;200(4):1763-1775. doi: 10.1007/s12011-021-02800-4. Epub 2021 Jun 25.
Royal jelly (RJ) and selenium (Se)-rich foods have well-known health benefits which are attributable to a broad range of pharmacologic effects including antioxidant, bacteriostatic, anticancer, and immunoregulatory activities. However, there was no study to combine Se with RJ. Here, Se-rich RJ (SRJ) was produced by feeding sodium selenite to honeybees (Apis mellifera). To further clarify the function of SRJ, mice were then fed RJ or SRJ for 30 days, and their antioxidant capacity and gut microbiota profile were analyzed. The results showed that SRJ treatment could more effectively increase glutathione peroxidase levels in the liver and kidney, as well as total antioxidant activity in the liver and superoxide dismutase level in the kidney. Additionally, the ratio of Firmicutes/Bacteroidetes and relative abundance of the Lachnospiraceae and Prevotellaceae families were increased, whereas the abundance of Helicobacterceae was decreased in mice treated with SRJ. At the genus level, SRJ increased the relative abundance of Lachnospiraceae NK4A136 group, Prevotellaceae UCG 001, Rikenellaceae RC9 gut group, and Oscillibacter and decreased that of Alistipes. And the functional prediction of gut microbiota indicated SRJ treatment could enhance the amino acid metabolism. Correlation analysis indicated that SRJ could optimize the functional network of gut microbiota and the interactions between the gut microbiota and the host. These results suggested the SRJ had potential therapeutic applications in the improvement of overall health or treatment of diseases related to oxidative stress or dysbiosis.
蜂王浆（RJ）和富硒食物具有众所周知的健康益处，这归因于其广泛的药理作用，包括抗氧化、抑菌、抗癌和免疫调节活性。然而，尚无将硒与蜂王浆结合的研究。在此，通过向蜜蜂（意大利蜜蜂）投喂亚硒酸钠来生产富硒蜂王浆（SRJ）。为了进一步阐明SRJ的功能，随后给小鼠喂食RJ或SRJ 30天，并分析它们的抗氧化能力和肠道微生物群特征。结果表明，SRJ处理能更有效地提高肝脏和肾脏中的谷胱甘肽过氧化物酶水平，以及肝脏中的总抗氧化活性和肾脏中的超氧化物歧化酶水平。此外，在接受SRJ处理的小鼠中，厚壁菌门/拟杆菌门的比例以及毛螺菌科和普雷沃氏菌科的相对丰度增加，而螺杆菌科的丰度降低。在属水平上，SRJ增加了毛螺菌科NK4A136组、普雷沃氏菌科UCG 001、理研菌科RC9肠道组和颤杆菌属的相对丰度，并降低了阿利斯杆菌属的相对丰度。肠道微生物群的功能预测表明，SRJ处理可增强氨基酸代谢。相关性分析表明，SRJ可优化肠道微生物群的功能网络以及肠道微生物群与宿主之间的相互作用。这些结果表明，SRJ在改善整体健康或治疗与氧化应激或生态失调相关的疾病方面具有潜在的治疗应用价值。
