[风险因素积累对口腔鳞状细胞癌风险的影响]
[Effect of the accumulation of risk factors on the risk of oral squamous cell carcinoma].
作者信息
Piemonte Eduardo David, Lazos Jerónimo Pablo, Belardinelli Paola, Castillo Graciela Del Valle, Talavera Angel Daniel, Secchi Dante Gustavo, Lanfranchi Tizeira Héctor Eduardo, Brunotto Mabel Noemí
机构信息
Facultad de Odontología, Universidad Nacional de Córdoba.
Facultad de odontología, Universidad Nacional de Córdoba.
出版信息
Rev Fac Cien Med Univ Nac Cordoba. 2021 Jun 28;78(2):158-165. doi: 10.31053/1853.0605.v78.n2.31247.
INTRODUCTION
the causative factors of oral squamous cell carcinoma are not necessary and not sufficient causes, even the most accepted ones, such as tobacco and alcohol. Little is known about the cumulative effect of all risk factors for oral cancer. The objective of this work was to analyze whether the sum of oral cancer risk factors is associated with an increase in its risk.
METHODS
a case-control study was carried out to determine the risk factors for oral cancer in the population under study, and then correlate the number of risk factors in each individual with the risk of oral cancer.
RESULTS
the accumulation of oral cancer risk factors, analyzed using different strategies, was always associated with a significant increase in the risk of oral cancer. Having 3 or more risk factors was associated with an increased risk of oral cancer (OR 110, p <0.0001)
CONCLUSION
the main risk factor for oral cancer is the accumulation of its risk factors. The accumulation of risk factors could be considered a necessary cause for the development of oral cancer.
引言
口腔鳞状细胞癌的致病因素并非必要且充分的病因，即使是最被认可的因素，如烟草和酒精。对于口腔癌所有风险因素的累积效应知之甚少。本研究的目的是分析口腔癌风险因素的总和是否与其风险增加相关。
方法
开展了一项病例对照研究，以确定所研究人群中口腔癌的风险因素，然后将每个个体的风险因素数量与口腔癌风险相关联。
结果
使用不同策略分析，口腔癌风险因素的累积始终与口腔癌风险的显著增加相关。有3个或更多风险因素与口腔癌风险增加相关（比值比110，p<0.0001）
结论
口腔癌的主要风险因素是其风险因素的累积。风险因素的累积可被视为口腔癌发生的必要病因。
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