Penn State College of Medicine, Hershey, PA.
Penn State College of Medicine, Hershey, PA; Division of Cardiac, Thoracic, and Vascular Surgery, Department of Surgery, New York-Presbyterian Hospital/Columbia University Medical Center, New York, NY.
Am J Infect Control. 2022 Feb;50(2):203-213. doi: 10.1016/j.ajic.2021.06.012. Epub 2021 Jun 25.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to over 170?million cases worldwide with over 33.2?million cases and 594,000 deaths in the US alone as of May 31st, 2021. The pandemic has also created severe shortages of personal protective equipment, particularly of filtering facepiece respirators (FFRs). The Centers for Disease Control and Prevention (CDC) has issued recommendations to help conserve FFRs, as well as crisis standards, including four criteria required for decontamination of the traditionally single use respirators. This review is designed to provide an overview of the current literature on vaporized hydrogen peroxide (vHP), hydrogen peroxide gas plasma (HPGP), and aerosolized hydrogen peroxide (aHP) with respect to each of the four CDC decontamination criteria.
PubMed and Medrxiv were queried for relevant articles. All articles underwent a title and abstract screen as well as subsequent full text screen by two blinded reviewers if indicated.
Searches yielded 195 papers, of which, 79 were found to be relevant. Of those, 23 papers presented unique findings and 8 additional articles and technical papers were added to provide a comprehensive review. Overall, while there are potential concerns for all 3 decontamination methods, we found that vHP has the most evidence supporting its use in FFR decontamination consistent with CDC recommendation.
Future research is recommended to evaluate biological inactivation and real world fit failures after FFR reuse.
由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）在全球范围内导致了超过 1.7 亿例病例，仅在美国就有超过 3320 万例病例和 59.4 万人死亡截至 2021 年 5 月 31 日。大流行还导致个人防护设备严重短缺，特别是过滤式面罩呼吸器（FFR）。疾病控制与预防中心（CDC）发布了建议，以帮助节约 FFR，并制定了危机标准，包括传统一次性使用呼吸器消毒所需的四项标准。本综述旨在概述关于汽化过氧化氢（vHP）、过氧化氢气体等离子体（HPGP）和雾化过氧化氢（aHP）的当前文献，针对 CDC 消毒的四项标准中的每一项。
在 PubMed 和 Medrxiv 上查询相关文章。如果需要，所有文章都由两名盲审员进行标题和摘要筛选以及随后的全文筛选。
搜索结果产生了 195 篇论文，其中 79 篇被认为是相关的。其中，23 篇论文提出了独特的发现，另外 8 篇文章和技术论文被添加进来提供了全面的综述。总的来说，虽然所有 3 种消毒方法都存在潜在的问题，但我们发现 vHP 最有证据支持其在 FFR 消毒中的使用符合 CDC 的建议。
建议进行未来的研究，以评估 FFR 重复使用后的生物失活和现实世界的拟合失败。
