哺乳与癌症风险：是否存在特定于乳腺癌的关联？
Lactation and cancer risk: is there a relation specific to breast cancer?
作者信息
Kvåle G, Heuch I
机构信息
Institute of Hygiene and Social Medicine, University of Bergen, Norway.
出版信息
J Epidemiol Community Health. 1988 Mar;42(1):30-7. doi: 10.1136/jech.42.1.30.
Relations between previous lactation experience and risks of cancer of the breast and other sites were investigated after follow-up of 50,274 parous women from 1961 through 1980. Among women with complete information on lactation, 5102 developed cancer and, of these, 1136 were diagnosed with breast cancer. Analyses of associations with mean duration of lactation per birth and duration for each of the three first births suggested a nonlinear relation to breast cancer. The highest risk was observed for those with intermediate duration of breast feeding, whereas lower risks were found among those with very short or very long duration. For all nongenital cancers combined, decreased risks were observed among those with the longest duration of breast feeding. However, among cancers of specific sites, a significant inverse association was found for pancreatic cancer only. The overall impression given by our data is that breast feeding is not strongly related to risks of breast cancer or any other common cancer.
在对1961年至1980年间的50274名经产妇进行随访后，研究了既往哺乳经历与乳腺癌及其他部位癌症风险之间的关系。在有完整哺乳信息的女性中，5102人患癌，其中1136人被诊断为乳腺癌。对每次分娩的平均哺乳时长以及头三次分娩中每次分娩的哺乳时长之间的关联分析表明，其与乳腺癌呈非线性关系。母乳喂养时长处于中等水平的女性患癌风险最高，而哺乳时长极短或极长的女性患癌风险较低。对于所有非生殖系统癌症而言，哺乳时长最长的女性患癌风险降低。然而，在特定部位的癌症中，仅胰腺癌存在显著的负相关。我们的数据总体显示，母乳喂养与乳腺癌或任何其他常见癌症的风险并无紧密关联。
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