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使用具有非线性发病率的改进型SLIR模型对COVID-19进行分析。

Analysis of COVID-19 using a modified SLIR model with nonlinear incidence.

作者信息

Kuddus Md Abdul, Rahman Azizur

机构信息

Department of Mathematics, University of Rajshahi, Rajshahi 6205, Bangladesh.

School of Computing and Mathematics, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.

出版信息

Results Phys. 2021 Aug;27:104478. doi: 10.1016/j.rinp.2021.104478. Epub 2021 Jun 21.

Abstract

Infectious diseases kill millions of people each year, and they are the major public health problem in the world. This paper presents a modified (SLIR) compartmental model of disease transmission with nonlinear incidence. We have obtained a threshold value of basic reproduction number and shown that only a disease-free equilibrium exists when and endemic equilibrium when . With the help of the Lyapunov-LaSalle Invariance Principle, we have shown that disease-free equilibrium and endemic equilibrium are both globally asymptotically stable. The study has also provided the model calibration to estimate parameters with month wise coronavirus (COVID-19) data, i.e. reported cases by worldometer from March 2020 to May 2021 and provides prediction until December 2021 in China. The Partial Rank Correlation Coefficient (PRCC) method was used to investigate how the model parameters' variation impact the model outcomes. We observed that the most important parameter is transmission rate which had the most significant impact on COVID-19 cases. We also discuss the epidemiology of COVID-19 cases and several control policies and make recommendations for controlling this disease in China.

摘要

传染病每年导致数百万人死亡,是全球主要的公共卫生问题。本文提出了一种具有非线性发病率的修正的疾病传播(SLIR) compartmental模型。我们得到了基本再生数的阈值,并表明当 时仅存在无病平衡点,当 时存在地方病平衡点。借助李雅普诺夫 - 拉萨尔不变性原理,我们证明了无病平衡点和地方病平衡点都是全局渐近稳定的。该研究还提供了模型校准,以利用逐月的冠状病毒(COVID - 19)数据估计参数,即2020年3月至2021年5月世界ometers网站报告的病例数,并对中国直至2021年12月的情况进行预测。使用偏秩相关系数(PRCC)方法研究模型参数的变化如何影响模型结果。我们观察到最重要的参数是传播率,它对COVID - 19病例数的影响最为显著。我们还讨论了COVID - 19病例的流行病学以及几种控制策略,并对中国控制这种疾病提出了建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b72b/8222049/ca029aa34853/gr1_lrg.jpg

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