环氧水化酶在苯并(a)芘的活化和失活中的双重作用。 - Suppr

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Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene.

作者信息

Bentley P, Oesch F, Glatt H

出版信息

Arch Toxicol. 1977 Dec 30;39(1-2):65-75. doi: 10.1007/BF00343276.

DOI:10.1007/BF00343276

PMID:341851

Abstract

摘要

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Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene.环氧水化酶在苯并(a)芘的活化和失活中的双重作用。

Arch Toxicol. 1977 Dec 30;39(1-2):65-75. doi: 10.1007/BF00343276.

Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites.与诱变代谢物控制相关的激活和失活酶的物种差异。

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Prevention of benzo(a)pyrene-induced mutagenicity by homogeneous epoxide hydratase.均一环氧水解酶对苯并(a)芘致突变性的预防作用

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Benzo(a)pyrene metabolism by purified forms of rabbit liver microsomal cytochrome P-450, cytochrome b5 and epoxide hydrase in reconstituted phospholipid vesicles.在重构磷脂囊泡中，纯化形式的兔肝微粒体细胞色素P-450、细胞色素b5和环氧化物水解酶对苯并(a)芘的代谢作用。

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Structural requirements for the metabolic activation of benzo[a]pyrene to mutagenic products: effects of modifications in the 4,5-, 7,8-, and 9,10-positions.苯并[a]芘代谢活化为诱变产物的结构要求：4,5-、7,8-和9,10-位修饰的影响

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Effect of purified epoxide hydrolase on metabolic activation and binding of benzo(a)pyrene to exogenous DNA. Shift of the activation pathway.纯化环氧水解酶对苯并(a)芘代谢活化及与外源DNA结合的影响。活化途径的转变。

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Effect of glutathione and uridine 5'-diphosphoglucuronic acid on benzo(a)pyrene mutagenesis in the Salmonella/microsome assay.谷胱甘肽和尿苷5'-二磷酸葡糖醛酸对沙门氏菌/微粒体试验中苯并(a)芘诱变作用的影响。

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Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization.谷胱甘肽S-转移酶对亲电子代谢物的灭活作用以及由于亚细胞定位导致的该系统的局限性。

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本文引用的文献

Effects of inducers and epoxide hydrase on the metabolism of benzo(a)pyrene by liver microsomes and a reconstituted system: analysis by high pressure liquid chromatography.诱导剂和环氧化物水解酶对肝脏微粒体及重组系统中苯并(a)芘代谢的影响：高压液相色谱分析

Proc Natl Acad Sci U S A. 1974 Nov;71(11):4356-60. doi: 10.1073/pnas.71.11.4356.

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide.苯并(a)芘的代谢活化通过二醇环氧化物进行。

Nature. 1974 Nov 22;252(5481):326-8. doi: 10.1038/252326a0.

High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane.苯并（α）芘代谢、共价结合的高压液相色谱分析以及7,8-苯并黄酮和1,2-环氧-3,3,3-三氯丙烷的作用机制

Cancer Res. 1974 Dec;34(12):3474-80.

Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.致癌物是诱变剂：一种将用于活化的肝脏匀浆和用于检测的细菌相结合的简单测试系统。

Proc Natl Acad Sci U S A. 1973 Aug;70(8):2281-5. doi: 10.1073/pnas.70.8.2281.

Exceptional mutagenicity of a benzo(a)pyrene diol epoxide in cultured mammalian cells.苯并(a)芘二醇环氧化物在培养的哺乳动物细胞中的超强致突变性。

Nature. 1976 May 6;261(5555):52-4. doi: 10.1038/261052a0.

Purification of rat liver epoxide hydratase to apparent homogeneity.大鼠肝脏环氧化物水合酶纯化至表观均一性。

FEBS Lett. 1975 Nov 15;59(2):291-5. doi: 10.1016/0014-5793(75)80395-4.

Metabolism of benzo[a]pyrene. Effect of substrate concentration and 3-methylcholanthrene pretreatment on hepatic metabolism by microsomes from rats and mice.苯并[a]芘的代谢。底物浓度和3-甲基胆蒽预处理对大鼠和小鼠微粒体肝脏代谢的影响。

Arch Biochem Biophys. 1975 Oct;170(2):557-66. doi: 10.1016/0003-9861(75)90151-4.

Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.苯并[a]芘4,5-、7,8-和9,10-氧化物以及六种相应酚类的致突变和细胞毒性活性。

Proc Natl Acad Sci U S A. 1975 Aug;72(8):3176-80. doi: 10.1073/pnas.72.8.3176.

Epoxides metabolically produced from some known carcinogens and from some clinically used drugs. I. Differences in mutagenicity.由某些已知致癌物和一些临床使用的药物代谢产生的环氧化物。I. 致突变性的差异。

Int J Cancer. 1975 Nov 15;16(5):787-97. doi: 10.1002/ijc.2910160511.

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.苯并[a]芘的代谢：（±）-反式-7,8-二羟基-7,8-二氢苯并[a]芘向高致突变性的7,8-二羟基-9,10-环氧化物的转化。

Proc Natl Acad Sci U S A. 1976 Oct;73(10):3381-5. doi: 10.1073/pnas.73.10.3381.

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