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新冠病毒感染后免疫功能正常患者发生的脑膜脑炎

Meningoencephalitis in an Immunocompetent Patient after COVID-19 Infection.

作者信息

Ghanem Hebah, Sivasubramanian Geetha

机构信息

Division of Infectious Diseases, Department of Internal Medicine, University of California, San Francisco, Fresno, California, USA.

出版信息

Case Rep Infect Dis. 2021 Jun 4;2021:5597473. doi: 10.1155/2021/5597473. eCollection 2021.

Abstract

is a saprophytic fungus that causes fatal disseminated infections in immunocompromised hosts. Since the onset of the COVID-19 pandemic, multiple cases of secondary viral, bacterial, and fungal infections have been reported in patients after SARS-CoV-2 infection. We describe here a case of severe cryptococcal meningitis that developed in a previously healthy patient one week after treatment of SARS-CoV-2 infection with dexamethasone. This case adds to the growing knowledge of emerging secondary infectious complications including opportunistic pathogens after SARS-CoV-2 infection. While few reports allude to depressed T-cell function and lymphopenia due to SARS-CoV-2 infection, further studies are needed to evaluate the effects of this infection and its treatment on the immune system and its contribution to the emergence of secondary opportunistic infections.

摘要

是一种腐生真菌,可在免疫功能低下的宿主中引起致命的播散性感染。自新冠疫情爆发以来,已有多例新冠病毒感染患者继发病毒、细菌和真菌感染的报告。我们在此描述一例严重隐球菌性脑膜炎病例,该病例发生在一名先前健康的患者身上,该患者在接受地塞米松治疗新冠病毒感染一周后发病。该病例增加了我们对新冠病毒感染后包括机会性病原体在内的新出现的继发性感染并发症的认识。虽然很少有报告提及新冠病毒感染导致的T细胞功能低下和淋巴细胞减少,但仍需要进一步研究来评估这种感染及其治疗对免疫系统的影响,以及其对继发性机会性感染出现的作用。

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本文引用的文献

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Cryptococcemia in a patient with COVID-19: A case report.一名新冠肺炎患者的隐球菌血症:病例报告
Clin Case Rep. 2020 Dec 19;9(2):853-855. doi: 10.1002/ccr3.3668. eCollection 2021 Feb.
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Cryptococcus: from environmental saprophyte to global pathogen.隐球菌:从环境腐生菌到全球病原体。
Nat Rev Microbiol. 2016 Feb;14(2):106-17. doi: 10.1038/nrmicro.2015.6. Epub 2015 Dec 21.

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