Ali Dina M, Zake Lamiaa G, El Kady Nevine K
Tropical Medicine Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
Chest Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.
Interdiscip Perspect Infect Dis. 2021 May 28;2021:8798575. doi: 10.1155/2021/8798575. eCollection 2021.
The current global pandemic of COVID-19 is considered a public health emergency. The diagnosis of COVID-19 depends on detection of the viral nucleic acid by real time reverse transcription polymerase chain reaction (RT-PCR). However, false-negative RT-PCR tests are reported and could hinder the control of the pandemic. Chest computed tomography could achieve a more reliable diagnosis and represent a complementary diagnostic tool.
To perform a meta-analysis and systematic review to find out the role of chest computed tomography versus RT-PCR for precise diagnosis of COVID-19 infection.
We searched three electronic databases (PubMed, ScienceDirect, and Scopus) from April 1 to April 20, 2020, to find out articles including the accuracy of chest computed tomography scan versus RT-PCR for diagnosis of SARS-CoV-2 infection. Observational studies, case series, and case reports were included.
A total of 238 articles were retrieved from the search strategy. Following screening, 39 articles were chosen for full text assessment and finally 35 articles were included for qualitative and quantitative analysis. Chest computed tomography showed a wide range of sensitivity varied from 12%-100%.
Chest computed tomography is playing a key role for diagnosis and detection of COVID-19 infection. Computed tomography image findings may precede the initially positive RT-PCR assay.
当前全球新冠疫情被视为突发公共卫生事件。新冠病毒病（COVID-19）的诊断依赖于实时逆转录聚合酶链反应（RT-PCR）检测病毒核酸。然而，有报道称RT-PCR检测存在假阴性情况，这可能会阻碍疫情防控。胸部计算机断层扫描可实现更可靠的诊断，是一种辅助诊断工具。
进行一项荟萃分析和系统评价，以明确胸部计算机断层扫描与RT-PCR在精准诊断COVID-19感染方面的作用。
我们于2020年4月1日至4月20日检索了三个电子数据库（PubMed、ScienceDirect和Scopus），以查找有关胸部计算机断层扫描与RT-PCR诊断严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染准确性的文章。纳入观察性研究、病例系列和病例报告。
通过检索策略共检索到238篇文章。经过筛选，39篇文章被选作全文评估，最终35篇文章被纳入定性和定量分析。胸部计算机断层扫描的敏感性范围很广，从12%到100%不等。
胸部计算机断层扫描在COVID-19感染的诊断和检测中发挥着关键作用。计算机断层扫描图像结果可能先于最初的RT-PCR检测呈阳性。
