Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, 43204 Reus, Spain.
Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain.
Nutrients. 2021 Jun 13;13(6):2032. doi: 10.3390/nu13062032.
We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with , and , which had higher abundance the overweight/obese subjects. Moreover, different genera of were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus , a biomarker of the overweight/obese group, whereas SFAs were positively associated with , a biomarker for the lean group. In conclusion, , and could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.
我们旨在区分超重/肥胖和正常体重人群的肠道微生物组成，并确定其与临床变量和饮食摄入的关系。这项横断面研究纳入了 96 名超重/肥胖受试者和 32 名正常体重受试者。人体测量参数与拟杆菌门、厚壁菌门和放线菌门呈正相关，这些菌门在超重/肥胖受试者中的丰度更高。此外，不同属的阿克曼氏菌与体脂、LDL 和总胆固醇呈负相关。饱和脂肪酸（SFAs）与超重/肥胖组的生物标志物阿克曼氏菌呈负相关，而 SFAs 与正常体重组的生物标志物双歧杆菌呈正相关。总之，拟杆菌门、厚壁菌门和放线菌门可以作为肥胖的生物标志物，阿克曼氏菌与心血管脂质风险因素有关。SFAs 与产生丁酸的细菌之间存在相反的关联模式，这取决于 BMI。因此，饮食与微生物组之间的关系为肥胖的管理提供了新的工具。
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