Department of Pharmaceutical Sciences, College of Pharmacy and Health Science, Ajman University, P.O. Box 346 Ajman, United Arab Emirates.
Center of Medical and Bio-Allied Health Sciences Research, Ajman University, P.O. Box 346 Ajman, United Arab Emirates.
Molecules. 2021 Jun 10;26(12):3553. doi: 10.3390/molecules26123553.
Multi-drug resistant pathogens are a rising danger for the future of mankind. Iodine (I) is a centuries-old microbicide, but leads to skin discoloration, irritation, and uncontrolled iodine release. Plants rich in phytochemicals have a long history in basic health care. Miller (AV) and L. (Sage) are effectively utilized against different ailments. Previously, we investigated the antimicrobial activities of smart triiodides and iodinated AV hybrids. In this work, we combined iodine with Sage extracts and pure AV gel with polyvinylpyrrolidone (PVP) as an encapsulating and stabilizing agent. Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), Surface-Enhanced Raman Spectroscopy (SERS), microstructural analysis by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-Ray-Diffraction (XRD) analysis verified the composition of AV-PVP-Sage-I. Antimicrobial properties were investigated by disc diffusion method against 10 reference microbial strains in comparison to gentamicin and nystatin. We impregnated surgical sutures with our biohybrid and tested their inhibitory effects. AV-PVP-Sage-I showed excellent to intermediate antimicrobial activity in discs and sutures. The iodine within the polymeric biomaterial AV-PVP-Sage-I and the synergistic action of the two plant extracts enhanced the microbial inhibition. Our compound has potential for use as an antifungal agent, disinfectant and coating material on sutures to prevent surgical site infections.
多药耐药病原体对人类的未来构成了日益严重的威胁。碘 (I) 是一种具有数百年历史的杀菌剂，但会导致皮肤变色、刺激和碘的失控释放。富含植物化学物质的植物在基本保健方面有着悠久的历史。AV 米勒和 S 圣人被有效地用于治疗不同的疾病。此前，我们研究了智能三碘化物和碘代 AV 杂种的抗菌活性。在这项工作中，我们将碘与 Sage 提取物和纯 AV 凝胶与聚乙烯吡咯烷酮 (PVP) 结合，PVP 作为一种封装和稳定剂。傅里叶变换红外光谱 (FT-IR)、紫外-可见光谱 (UV-Vis)、表面增强拉曼光谱 (SERS)、扫描电子显微镜 (SEM) 的微观结构分析、能谱 (EDS) 和 X 射线衍射 (XRD) 分析证实了 AV-PVP-Sage-I 的组成。通过圆盘扩散法对 10 种参考微生物菌株进行了抗菌性能研究，并与庆大霉素和制霉菌素进行了比较。我们用我们的生物杂种浸渍手术缝线，并测试了它们的抑制效果。AV-PVP-Sage-I 在圆盘和缝线中表现出极好到中等的抗菌活性。聚合物生物材料 AV-PVP-Sage-I 中的碘和两种植物提取物的协同作用增强了微生物的抑制作用。我们的化合物具有作为抗真菌剂、消毒剂和缝线涂层材料的潜力，以防止手术部位感染。
