Bhatia Priya, Sharma Anushka, George Abhilash J, Anvitha D, Kumar Pragya, Dwivedi Ved Prakash, Chandra Nidhi S
Department of Microbiology, Ram Lal Anand College, University of Delhi, Benito Juarez Road, New Delhi 110021, India.
Immunobiology Group, International Center for Genetic Engineering and Biotechnology, New Delhi 110067, India.
Heliyon. 2021 Feb 20;7(2):e06310. doi: 10.1016/j.heliyon.2021.e06310. eCollection 2021 Feb.
Antibiotic resistance has emerged as a threat to global health, food security, and development today. Antibiotic resistance can occur naturally but mainly due to misuse or overuse of antibiotics, which results in recalcitrant infections and Antimicrobial Resistance (AMR) among bacterial pathogens. These mainly include the MDR strains (multi-drug resistant) of ESKAPE (, , , , , and species). These bacterial pathogens have the potential to "escape" antibiotics and other traditional therapies. These bacterial pathogens are responsible for the major cases of Hospital-Acquired Infections (HAI) globally. ESKAPE Pathogens have been placed in the list of 12 bacteria by World Health Organisation (WHO), against which development of new antibiotics is vital. It not only results in prolonged hospital stays but also higher medical costs and higher mortality. Therefore, new antimicrobials need to be developed to battle the rapidly evolving pathogens. Plants are known to synthesize an array of secondary metabolites referred as phytochemicals that have disease prevention properties. Potential efficacy and minimum to no side effects are the key advantages of plant-derived products, making them suitable choices for medical treatments. Hence, this review attempts to highlight and discuss the application of plant-derived compounds and extracts against ESKAPE Pathogens.
抗生素耐药性如今已成为对全球健康、粮食安全和发展的一大威胁。抗生素耐药性可自然产生，但主要是由于抗生素的滥用或过度使用，这导致细菌病原体中出现难治性感染和抗菌药物耐药性（AMR）。这些主要包括ESKAPE（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和阴沟肠杆菌）的多重耐药（MDR）菌株。这些细菌病原体有可能“逃脱”抗生素和其他传统疗法。这些细菌病原体是全球医院获得性感染（HAI）主要病例的罪魁祸首。ESKAPE病原体已被世界卫生组织（WHO）列入12种细菌名单，针对这些细菌研发新抗生素至关重要。它不仅会导致住院时间延长，还会带来更高的医疗成本和更高的死亡率。因此，需要研发新的抗菌药物来对抗快速演变的病原体。众所周知，植物能合成一系列具有疾病预防特性的次生代谢产物，即植物化学物质。植物源产品的潜在疗效以及极小或无副作用是其关键优势，使其成为医疗治疗的合适选择。因此，本综述试图突出并讨论植物源化合物和提取物针对ESKAPE病原体的应用。
