Esperança-Martins Miguel, Fernandes Isabel, Soares do Brito Joaquim, Macedo Daniela, Vasques Hugo, Serafim Teresa, Costa Luís, Dias Sérgio
Centro Hospitalar Universitário Lisboa Norte, Medical Oncology Department, Hospital Santa Maria, 1649-028 Lisboa, Portugal.
Vascular Biology & Cancer Microenvironment Lab, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
Cells. 2021 Jun 8;10(6):1432. doi: 10.3390/cells10061432.
The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction-oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics.
癌细胞能够呈现出大量的代谢适应性变化，这些变化不仅支持其生物合成活动，还满足其生物能量需求，并维持细胞内的氧化还原平衡。最近，人们将重点放在了癌细胞用于增殖的能量代谢重编程策略上。关于软组织和骨肉瘤代谢组的知识相对较少。肉瘤代谢格局的进一步特征描述可能为诊断的优化和新治疗靶点的识别铺平道路，从而使肉瘤患者受益。本综述涵盖了癌症代谢组学的最新知识，并详细探讨了软组织和骨肉瘤代谢组学的最新证据。
