Biotechnology Research Center, Pharmaceutical Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad 91735, Iran.
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Int J Mol Sci. 2021 Jun 8;22(12):6203. doi: 10.3390/ijms22126203.
Hydrogels are known as water-swollen networks formed from naturally derived or synthetic polymers. They have a high potential for medical applications and play a crucial role in tissue repair and remodeling. MSC-derived exosomes are considered to be new entities for cell-free treatment in different human diseases. Recent progress in cell-free bone tissue engineering via combining exosomes obtained from human mesenchymal stem cells (MSCs) with hydrogel scaffolds has resulted in improvement of the methodologies in bone tissue engineering. Our research has been actively focused on application of biotechnological methods for improving osteogenesis and bone healing. The following text presents a concise review of the methodologies of fabrication and preparation of hydrogels that includes the exosome loading properties of hydrogels for bone regenerative applications.
水凝胶是由天然或合成聚合物形成的溶胀网络，具有很高的医学应用潜力，在组织修复和重塑中发挥着关键作用。MSC 衍生的外体被认为是不同人类疾病中无细胞治疗的新实体。最近，通过将人骨髓间充质干细胞（MSCs）衍生的外体与水凝胶支架结合进行无细胞骨组织工程方面的进展，改进了骨组织工程的方法。我们的研究一直积极关注应用生物技术方法来提高成骨和骨愈合。本文简要综述了水凝胶的制备和制备方法，包括水凝胶的外体负载特性及其在骨再生应用中的研究进展。
