Surgery, UMC Utrecht, Utrecht, The Netherlands.
Gastroenterology and Hepatology, UMC Utrecht, Utrecht, The Netherlands.
BMJ Open Gastroenterol. 2021 Jul;8(1). doi: 10.1136/bmjgast-2021-000670.
COVID-19 has put a strain on regular healthcare worldwide. For inflammatory bowel disease (IBD), gastrointestinal surgeries were postponed and changes in treatment and diagnostic procedures were made. As abrupt changes in treatment regimens may result in an increased morbidity and consequent well-being of patients with IBD, the aim of this study was to determine the effect of the COVID-19 pandemic on health-related quality of life (HRQoL) in patients with IBD.
All patients with IBD who completed both Inflammatory Bowel Disease Questionnaire (IBDQ) and 36-Item Short Form Health Survey (SF-36) questionnaire between 31 August and 13 September 2020 were included in our cohort study. The primary end point was to determine the HRQoL in patients with IBD, measured by the IBDQ and SF-36 questionnaire. The secondary end point was determining which factors influence the HRQoL in patients with IBD.
582 patients with IBD filled in the IBDQ and SF-36 questionnaire. The HRQoL in our study population was low according to the questionnaires on both physical and mental subscales. In addition, multivariate analysis showed that increased age, female sex and patients who underwent surgery had a significantly lower HRQoL, most frequently on the physical domains in both questionnaires.
Patients with IBD had an overall low HRQoL during the COVID-19 pandemic. Furthermore, older patients, women and patients who underwent surgical procedures had the lowest physical HRQoL.
COVID-19 给全球常规医疗保健带来了压力。对于炎症性肠病（IBD），胃肠道手术被推迟，治疗和诊断程序发生了变化。由于治疗方案的突然改变可能导致 IBD 患者的发病率增加，继而对其健康状况产生影响，因此本研究旨在确定 COVID-19 大流行对 IBD 患者健康相关生活质量（HRQoL）的影响。
本队列研究纳入了所有在 2020 年 8 月 31 日至 9 月 13 日期间完成炎症性肠病问卷（IBDQ）和 36 项简短健康调查问卷（SF-36）的 IBD 患者。主要终点是通过 IBDQ 和 SF-36 问卷确定 IBD 患者的 HRQoL。次要终点是确定哪些因素影响 IBD 患者的 HRQoL。
582 例 IBD 患者填写了 IBDQ 和 SF-36 问卷。根据两份问卷的身体和心理子量表，我们研究人群的 HRQoL 较低。此外，多变量分析显示，年龄较大、女性和接受手术的患者 HRQoL 显著降低，在两份问卷的身体领域最为常见。
在 COVID-19 大流行期间，IBD 患者的总体 HRQoL 较低。此外，年龄较大、女性和接受手术的患者的身体 HRQoL 最低。
